publication

62. Benzoate Cyclometalation Enables Oxidative Addition of Haloarenes at a Ru(II) Center
Marco Simonetti, Rositha Kuniyil, Stuart A. Macgregor, and Igor Larrosa* J. Am. Chem. Soc. 2018, 140, 11836-11847

pub 60

61. meta-C–H arylation of fluoroarenes via traceless directing group relay strategy
Marc Font, Andrew R. A. Spencer, Igor Larrosa* Chem. Sci. 2018, 9, 7133-7137

Highlighted in Synfacts 2018, 14, 1073

pub 60

60. Ag(I)–C–H Activation Enables Near-Room-Temperature Direct α-Arylation of Benzo[b]thiophenes
Chiara Colletto, Adyasha Panigrahi, Jamie Fernández-Casado, Igor Larrosa* J. Am. Chem. Soc 2018, 140, 9638-9643

pub 60

59. Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals
Marco Simonetti, Diego M. Cannas, Xavier Just-Baringo, Iñigo J. Vitorica-Yrezabal, Igor Larrosa* Nature Chemistry 2018, 10, 724-731

Highlighted in Synform 2018, A172-A174

pub 59

58. Ketone C–C Bond Activation Meets the Suzuki-Miyaura Cross-coupling
Xavier Just-Baringo, Igor Larrosa* Chem 2018, 4, 1203-1204

57. Two prime or not two prime
Andrew Spencer, Rocio Lopez-Rodriguez, Igor Larrosa* Nature Catalysis (News and Views) 2018, 1, 381-382

56. Transition-metal-free decarboxylative bromination of aromatic carboxylic acids
Jacob M. Quibell, Gregory J. P. Perry, Diego M. Cannas, Igor Larrosa* Chem. Sci. 2018, 9, 3860-3865

pub 56


55. Reaction monitoring reveals poisoning mechanism of Pd2(dba)3 and guides catalyst selection
Chiara Colletto, Jordi Burés,* Igor Larrosa* Chem. Commun.2017, 53, 12890-12893

pub 55


54. A Direct Arylation-Cyclization Reaction for the Construction of Medium-Sized Rings
Daniel Whitaker, Maria Batuecas, Paolo Ricci, Igor Larrosa* Chem. Eur. J. 2017, 23, 12763-12766

pub 54


53. Transition Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings
Gregory J. P. Perry, Jacob M. Quibell, Adyasha Panigrahi, Igor Larrosa* J. Am. Chem. Soc 2017, 139, 11527-11536

pub 53


52. C-H carboxylation of aromatic compounds via CO2 fixation
Junfei Luo, Igor Larrosa* ChemSusChem 2017, 10, 3317-3332

pub 52


51. Biaryl Synthesis via C-H Bond Activation: Strategies and Methods
Marco Simonetti, Diego M. Cannas, Igor Larrosa* Advances in Organometallic Chemistry 2017, 67, 299-399


50. Determination of 2H KIEs from Competition Experiments: Increased Accuracy via Isotopic Enrichment
Chiara Colletto, Daniel Whitaker, Igor Larrosa* Top. Catal. 2017, 60, 589-593

pub 45

49. Recent Progress in Decarboxylative Oxidative Cross-Coupling for Biaryl Synthesis
Gregory J. P. Perry, Igor Larrosa* Eur. J. Org. Chem. 2017, 25, 3517-3527


48. The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation
Marc Font, Jacob Quibell, Gregory J. P. Perry, Igor Larrosa* Chem. Commun. 2017, 53, 5584-5597

pub 45


47. Photoelectrocatalysis of Rhodamine B and Solar Hydrogen Production by TiO2 and Pd/TiO2 Catalyst Systems
Pelin Yilmaz, Armando M. Lacerda, Igor Larrosa*, Steve Dunn* Electrochimica Acta 2017, 231,641-649


46. Ruthenium-Catalyzed C-H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides
Marco Simonetti, Diego M. Cannas, Adyasha Panigrahi, Szymon Kujawa, Michal Kryjewski, Pan Xie, Igor Larrosa*
Chem. Eur. J. 2017, 23, 549-543

pub 44


45. Direct ortho-Arylation of Pyridinecarboxylic Acids: Overcoming the Deactivating Effect of sp2-Nitrogen
Adam J. S. Johnston, Kenneth B. Ling, David Sale, Nathalie Lebrasseur, Igor Larrosa* Org. Lett. 2016, 18, 6094-6097

pub 45


44. C–H activation: Good things come in threes
Marco Simonetti, Igor Larrosa* Nature Chemistry (News and Views) 2016, 8, 1086-1088


43. Ag(I)-catalyzed C-H activation: the role of the Ag(I) salt in Pd/Ag mediated C-H arylation of electron-deficient arenes
Daniel Whitaker, Jordi Burés,* Igor Larrosa* J. Am. Chem. Soc. 2016, 138, 8384-8387

pub 43


42. Carboxylation of Phenols with CO2 at Atmospheric Pressure
Junfei Luo, Sara Preciado, Pan Xie, Igor Larrosa*
Chem. Eur. J. 2016, 22, 6798-6802

pub 42


41. Ru-Catalyzed C–H Arylation of Fluoroarenes with Aryl Halides
Marco Simonetti, Gregory J. P. Perry, Xacobe C. Cambeiro, Francisco Juliá-Hernández, Jude N. Arokianathar, Igor Larrosa*
J. Am. Chem. Soc. 2016, 138, 3596-3606

pub 41


40. Room Temperature Direct β-Arylation of Thiophenes and Benzo[b]thiophenes and Kinetic Evidence for a Heck-type Pathway
Chiara Colletto, Saidul Islam, Francisco Juliá-Hernández, Igor Larrosa* J. Am. Chem. Soc. 2016, 138, 1677-1683

pub 40


39. Au-Catalyzed Cross-Coupling of Arenes via Double C–H Activation
Xacobe C. Cambeiro, Nanna Ahlsten, Igor Larrosa* J. Am. Chem. Soc. 2015, 137, 15636-15639

pub 39


38. Plasmon enhanced visible light photocatalysis for TiO2 supported Pd nanoparticles
Armando Lacerda, Igor Larrosa*, Steve Dunn* Nanoscale 2015, 7, 12331-12335

pub 38


37. A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols
Junfei Luo, Solomon Araromi, Sara Preciado, Igor Larrosa* Chem. Asian J. 2016, 11, 347-350

pub 37


36. Selective and general exhaustive cross-coupling of di-chloroarenes with a deficit of nucleophiles mediated by a Pd-NHC complex
Benjamin J. Groombridge, Stephen M. Goldup,* Igor Larrosa* Chem. Commun. 2015, 51, 3832-3834.

pub 36


35. Salicylic Acids as Readily Available Starting Materials for the synthesis of meta-Substituted Biaryls
Junfei Luo, Sara Preciado, Igor Larrosa* Chem. Commun. 2015, 51, 3127-3130.

Highlighted in Synfacts 2015, 0419

pub 35


34. Tuning Reactivity and Site Selectivity of Simple Arenes in C–H Activation: Ortho-Arylation of Anisoles via Arene–Metal π-Complexation
Paolo Ricci, Katrina Krämer, Igor Larrosa* J. Am. Chem. Soc. 2014, 136, 18082-18086.

pub 34


33. The ortho-Substituent Effect on the Ag-Catalysed Decarboxylation of Benzoic Acids
Rachel Grainger, Josep Cornella, David C. Blakemore, Igor Larrosa* Josep M. Campanera*
Chem. Eur. J. 2014, 20, 16680-16687.

pub 33


32. An organic cation as a silver(I) analogue for the arylation of sp2 and sp3 C–H bonds with iodoarenes
Carlos Arroniz, J. Gabriel Denis, Alan Ironmonger, Gerasimos Rassias, Igor Larrosa*
Chem. Sci. 2014, 5, 3509-3514.

In the news: The Chemical Engineer
Highlighted in Synfacts 2013, 1149

pub 32


31. Overriding Ortho-Para Selectivity via a Traceless Directing Group Relay Strategy: The Meta-Selective Arylation of Phenols
Junfei Luo, Sara Preciado, Igor Larrosa*
J. Am. Chem. Soc. 2014, 136, 4109-12.

Featured in Nature Chemistry 2014, 6, 375.

Angew. Chem. Int. Ed. 2014, 53, 7710-7712.

Chemistry World, July 2014



pub 31


30. On Water, Phosphine-Free Palladium-Catalyzed Room Temperature C–H Arylation of Indoles
Saidul Islam, Igor Larrosa*
Chem. Eur. J. 2013, 19, 15093-96.

pub 30


29. Metalation Dictates Remote Regioselectivity: Ruthenium-Catalyzed Functionalization of meta CAr–H Bonds
Francisco Juliá-Hernández, Marco Simonetti, Igor Larrosa*
Angew. Chem. Int. Ed. 2013, 52, 11458-60.

pub 29


28. Arene-Metal π-Complexation as a Traceless Reactivity Enhancer for C–H Arylation
Paolo Ricci, Katrina Krämer, Xacobe C. Cambeiro, Igor Larrosa*
J. Am. Chem. Soc. 2013, 135, 13258-61.

pub 28


27. A silver-free system for the direct C–H auration of arenes and heteroarenes from gold chloride complexes
Nanna Ahlsten, Gregory J. P. Perry, Xacobe C. Cambeiro, Tanya C. Boormana, Igor Larrosa*
Catal. Sci. Technol. 2013, 3, 2892-2897(Hot Article)

pub 27


26. Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation
Carlos Arroniz, Alan Ironmonger, Gerry Rassias, Igor Larrosa*
Org. Lett. 2013, 15, 910-3.

pub 26


25. Redox-Controlled Selectivity of C–H Activation in Oxidative Cross-Coupling of Arenes
Xacobe C. Cambeiro, Tanya C. Boorman, Pengfei Lu, Igor Larrosa*
Angew. Chem. Int. Ed. 2013, 52, 1781-4 (Hot Paper).

Highlighted in Synfacts 2013, 430.

pub 25



24. Selective Deuteration of (Hetero)aromatic Compounds via Deutero-decarboxylation of Carboxylic Acids
Rachel Grainger, Arif Nikmal, Josep Cornella, Igor Larrosa*
Org. Biomol. Chem. 2012, 10, 3172-4.

pub 24



23. Decarboxylative Carbon–Carbon Bond-Forming Transformations of (Hetero)aromatic Carboxylic Acids
Josep Cornella, Igor Larrosa*
Synthesis 2012, 653-76.

pub 23



22. Recent Advances in the C2 and C3 Regioselective Direct Arylation of Indoles
Nathalie Lebrasseur, Igor Larrosa
Advances in Heterocyclic Chemistry, Vol. 105 2012, 309-351.
(Ed. A. Katritzky, USA: Academic Press)

pub 22



21. Carboxylic Acids as Traceless Directing Groups for Formal meta-Selective Direct Arylation
Josep Cornella, Marika Righi, Igor Larrosa*
Angew. Chem. Int. Ed. 2011, 40, 9429-32.

pub 20



20. A Novel Mode of Reactivity for Gold(I): the decarboxylative aureation of (hetero)aromatic carboxylic acids
Josep Cornella, Martin Rosillo-Lopez, Igor Larrosa*
Adv. Synth. Catal. 2011, 353, 1359-66.

pub 19



19. Two Flavors of PEPPSI-IPr: Activation and Diffusion Control in a Single NHC-Ligated Pd Catalyst?
Igor Larrosa*, Clara Somoza, Alexandre Banquy, Stephen M. Goldup*
Org. Lett. 2011, 13, 146-9.

pub 18



18. Gold(I)-mediated C–H functionalization
Tanya Boorman, Igor Larrosa*
Chem. Soc. Rev. 2011, 40, 1910-25.

pub 17



17. Decarboxylative homocoupling of (hetero)aromatic carboxylic acids
Josep Cornella, Hicham Lahlali, Igor Larrosa*
Chem. Commun. 2010, 46, 8276-8278.

pub 16



16. Recent Advances in the C-2 Regioselective Direct Arylation of Indoles
Tanya Boorman, Igor Larrosa*
Progress in Heterocyclic Chemistry, Vol. 22 2010, 1-20.
(Eds. G. W. Gribble and J. A. Joule, Burlington: Academic Press)

pub 15



15. Gold(I)-Mediated C–H Activation of Arenes
Pengfei Lu, Tanya Boorman, Alexandra M. Z. Slawin, Igor Larrosa*
J. Am. Chem. Soc. 2010, 132, 5580-1.

pub 14



14. Silver-Catalyzed Protodecarboxylation of Heteroaromatic Carboxylic Acids
Pengfei Lu, Carolina Sanchez, Josep Cornella, Igor Larrosa*
Org. Lett. 2009, 11, 5710-3.

Highlighted in Synfacts 2010, 338.

pub 13



13. Intermolecular decarboxylative direct C-3 arylation of indoles with benzoic acids
Josep Cornella, Pengfei Lu, Igor Larrosa*
Org. Lett. 2009, 11, 5506-9.

Highlighted in Org. Proc. Res. & Dev. 2010,14, 300.

pub 12



12. Ag-catalysed protodecarboxylation of ortho substituted benzoic acids
Josep Cornella, Carolina Sanchez, David Banawa, Igor Larrosa*
Chem. Commun. 2009, 7176-8.

pub 11



11. Room temperature and phosphine free palladium catalyzed direct C-2 arylation of indoles
Nathalie Lebrasseur, Igor Larrosa
J. Am. Chem. Soc. 2008, 130, 2926-7.

Highlighted in Org. Proc. Res. & Dev. 2008,12, 548.

pub 9



10. Studies on the Total Synthesis of Lactonamycin: Synthesis of the Fused Pentacyclic B-F Ring Unit
Sylvain A. Jacques, Simon Michaelis, Bjorn Gebhardt, Andreas Blum, Nathalie Lebrasseur, Igor Larrosa, Andrew J. P. White, Anthony G. M. Barrett
Eur. J. Org. Chem. 2012, 107-13.

9. Stereoselective synthesis of alpha- and beta-C-glycosides by addition of titanium enolates to glycals
Erik Galvez, Igor Larrosa, Pedro Romea, Felix Urpi
Synlett 2009, 2982-6.

8. Synthesis of six-membered oxygenated heterocycles through carbon-oxygen bond-forming reactions (Report)
Igor Larrosa, Pedro Romea, Felix Urpi
Tetrahedron 2008, 64, 2683-2723.

7. Highly convergent three component benzyne coupling: the total synthesis of ent-clavilactone B
Igor Larrosa, Marianne I. Da Silva, Patricio M. Gomez, Peter Hannen, Eunjung Ko, Steven R. Lenger, Simon R. Linke, Andrew J. P. White, Donna Wilton, Anthony G. M. Barrett
J. Am. Chem. Soc. 2006, 128, 14042-3.

pub 7



6. Stereoselective Synthesis of the Western Hemisphere of Salinomycin
Igor Larrosa, Pedro Romea, Felix Urpi
Org. Lett. 2006, 8, 527-30.

5. Bismuth-catalyzed benzylic oxidations with tertbutyl hydroperoxide
Yannick Bonvin, Emmanuel Callens, Igor Larrosa, David A. Henderson, James Oldham, Andrew J. Burton, Anthony G. M. Barrett
Org. Lett. 2005, 7, 4549-52.

4. Mild cleavage of aryl mesylates: methane sulfonate as potent protecting group for phenols
Tobias Ritter, Kyril Stanek, Igor Larrosa, Erick M. Carreira
Org. Lett. 2004, 6, 1513-4.

3. Studies on the intramolecular C-H --- X (X = O, S) interactions in (S)-N-acyl- 4-isopropyl- 1,3 -thiazolidine- 2-thiones and related 1,3-oxazolidin- 2-ones
Anabel Cosp, Igor Larrosa, Josep M. Anglada, Josep M. Bofill, Pedro Romea, Felix Urpi
Org. Lett. 2003, 5, 2809-12.

2. Synthesis of O-benzyl protected anti aldol adducts through the cross-coupling reaction of dibenzyl acetals and a chiral titanium enolate
Anabel Cosp, Igor Larrosa, Irina Vilasis, Pedro Romea, Felix Urpi, Jaume Vilarrasa
Synlett 2003, 1109-12.

1. Unprecedented highly stereoselective alpha- and beta-C-glycosidation with chiral titanium enolates
Igor Larrosa, Pedro Romea, Felix Urpi, Daniel Balsells, Jaume Vilarrasa, Merce Font-Bardia, Xavier Solans
Org. Lett. 2002, 4, 4651-4.