Publications

2025

The Mechanism of Ru-catalyzed Directed C–H Arylation of Arenes: the Key Role of Bis-Cyclometalated Intermediates

Angewandte Chemie - International Edition, 2025, e202506707

Pablo Domingo-Legarda, Samuel E. Neale, Amber Carpentier, Claire L. McMullin, Michael Findlay, Igor Larrosa, Stuart A. Macgregor

Cover image for The Mechanism of Ru-catalyzed Directed C–H Arylation of Arenes: the Key Role of Bis-Cyclometalated Intermediates

Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp2)–H functionalization

Nature Catalysis, 2025,

Jamie H. Docherty, Mishra Deepak Hareram, Luke M. Nichols, Ignacio Perez-Ortega, Iñigo J. Vitorica-Yrezabal, Igor Larrosa

Cover image for Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp2)–H functionalization

Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

Journal of the American Chemical Society, 2025, ASAP

Kurt Bentley, Mishra Deepak Hareram, Gang-Wei Wang, Alexander A. V. Millman, Ignacio Perez-Ortega, Luke M. Nichols, Cassandre C. Bories, Lauren E. Walker, Adam W. Woodward, Alexander P. Golovanov, Louise S. Natrajan, Igor Larrosa

Cover image for Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions

PLOS ONE, 2025, 20(1)

Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M. Foster, Finlay A. Martin, Kira Brüninghoff, Kathleen M. Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V. Forment, Matthew J. Cliff, Igor Larrosa, Perdita Barran, Duncan L. Smith, Henning D. Mootz, Christine K. Schmidt

Cover image for Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions

Engineered enzymes for enantioselective nucleophilic aromatic substitutions

Nature, 2025, ASAP

Thomas M. Lister, George W. Roberts, Euan J. Hossack, Fei Zhao, Ashleigh J. Burke, Linus O. Johannissen, Florence J. Hardy, Alexander A. V. Millman, David Leys, Igor Larrosa, Anthony P. Green

Cover image for Engineered enzymes for enantioselective nucleophilic aromatic substitutions

2024

An air- and moisture-stable ruthenium precatalyst for diverse reactivity

Nature Chemistry, 2024, 16, 1141–1150

Gillian McArthur, Jamie H. Docherty, Mishra Deepak Hareram, Marco Simonetti, Iñigo J. Vitorica-Yrezabal, James J. Douglas, Igor Larrosa

Cover image for An air- and moisture-stable ruthenium precatalyst for diverse reactivity

Small-Molecule Inhibition of CBX4/7 Hypersensitises Homologous Recombination-Impaired Cancer to Radiation by Compromising CtIP-Mediated DNA End Resection

Cancers, 2024, 16, 1141–1150

Hugh C. Osborne, Benjamin M. Foster, Hazim Al-Hazmi, Stefan Meyer, Igor Larrosa, Christine K. Schmidt

Electrochemical Ruthenium‐Catalysed Directed C−H Functionalization of Arenes with Boron Reagents

Advanced Synthesis & Catalysis, 2024, 366, 830-837

Jacob Kenyon, Igor Larrosa

Cover image for Electrochemical Ruthenium‐Catalysed Directed C−H Functionalization of Arenes with Boron Reagents

Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control

Nature Communications, 2024, 15, 31

Peng-Bo Bai, Alastair Durie, Gang-Wei Wang, Igor Larrosa

Cover image for Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control

2023

Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules

Chemical Reviews, 2023, 123, 7692-7760

Jamie H. Docherty, Thomas M. Lister, Gillian Mcarthur, Michael T. Findlay, Pablo Domingo-Legarda, Jacob Kenyon, Shweta Choudhary, Igor Larrosa

Cover image for Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules

Carboxylic Acid Salts as Dual‐Function Reagents for Carboxylation and Carbon Isotope Labeling

Angewandte Chemie International Edition, 2023, 62, e202218371

Shuo Wang, Igor Larrosa, Hideki Yorimitsu, Gregory J. P. Perry

Cover image for Carboxylic Acid Salts as Dual‐Function Reagents for Carboxylation and Carbon Isotope Labeling

Organic reaction mechanism classification using machine learning

Nature, 2023, 613, 689–695

Jordi Burés, Igor Larrosa

Cover image for Organic reaction mechanism classification using machine learning

Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

Green Chemistry, 2023, 25, 2394-2400

Michael T. Findlay, Ashley S. Hogg, James J. Douglas, Igor Larrosa

Cover image for Improving the sustainability of the ruthenium-catalysed N-directed C–H arylation of arenes with aryl halides

2022

Ruthenium-Catalyzed Monoselective C–H Methylation and d3-Methylation of Arenes

JACS Au, 2022, 2, 11, 2529–2538

Ashley Hogg, Matthew Wheatley, Pablo Domingo-Legarda, Asier Carral-Menoyo, Naomi Cottam, Igor Larrosa

Cover image for Ruthenium-Catalyzed Monoselective C–H Methylation and d3-Methylation of Arenes

Effects of Lateral Size, Thickness, and Stabilizer Concentration on the Cytotoxicity of Defect-Free Graphene Nanosheets: Implications for Biological Applications

ACS Applied Nano Materials, 2022, 5, 9, 12626–12636

Chen-Xia Hu, Oliver Read, Yuyoung Shin, Yingxian Chen, Jingjing Wang, Matthew Boyes, Niting Zeng, Adyasha Panigrahi, Kostas Kostarelos, Igor Larrosa, Sandra Vranic, Cinzia Casiraghi

Cover image for Effects of Lateral Size, Thickness, and Stabilizer Concentration on the Cytotoxicity of Defect-Free Graphene Nanosheets: Implications for Biological Applications

A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation

Chemical Science, 2022, 13, 13225-13230

Shweta Choudhary, Diego M. Cannas, Matthew Wheatley, Igor Larrosa

Cover image for A manganese(i)tricarbonyl-catalyst for near room temperature alkene and alkyne hydroarylation

Catalysis with cycloruthenated complexes

Chemical Science, 2022, 13, 3335-3362

Michael T. Findlay, Pablo Domingo-Legarda, Gillian McArthur, Andy Yen, Igor Larrosa

Cover image for Catalysis with cycloruthenated complexes

Insights into the exfoliation mechanism of pyrene-assisted liquid phase exfoliation of graphene from lateral size-thickness characterisation

Carbon, 2022, 186, 550-559

Oliver Read, Yuyoung Shin, Chen-xia Hu, Marco Zarattini, Matthew Boyes, Xavier Just-Baringo, Adyasha Panigrahi, Igor Larrosa, Cinzia Casiraghi

Cover image for Insights into the exfoliation mechanism of pyrene-assisted liquid phase exfoliation of graphene from lateral size-thickness characterisation

Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells

International Journal of Molecular Sciences, 2022, 23(3), 1116

Hugh C. Osborne, Igor Larrosa, Christine K. Schmidt

Cover image for Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells

2021

Ru-catalyzed room-temperature alkylation and late-stage alkylation of arenes with primary alkyl bromides

Chem Catalysis, 2021, 1(3), 691-703

Matthew Wheatley, Michael T. Findlay, Rocío López-Rodríguez, Diego M. Cannas, Marco Simonetti, Igor Larrosa

Cover image for Ru-catalyzed room-temperature alkylation and late-stage alkylation of arenes with primary alkyl bromides

Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

ACS Catalysis, 2021, 11, 5, 2865–2878

Karl A. P. Payne, Stephen A. Marshall, Karl Fisher, Stephen E. J. Rigby, Matthew J. Cliff, Reynard Spiess, Diego M. Cannas, Igor Larrosa, Sam Hay, David Leys

Cover image for Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence

Enhanced liquid phase exfoliation of graphene in water using an insoluble bis-pyrene stabiliser

Faraday Discussions, 2021, 227, 46-60

Yuyoung Shin, Xavier Just-Baringo, Matthew Boyes, Adyasha Panigrahi, Marco Zarattini, Yingxian Chen, Xinyun Liu, Gareth Morris, Eric Prestat, Kostas Kostarelos, Sandra Vranic, Igor Larrosa, Cinzia Casiraghi

2020

Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides

ACS Catalysis, 2020, 10, 3, 2100–2107

Adyasha Panigrahi, Daniel Whitaker, Iñigo J. Vitorica-Yrezabal, Igor Larrosa

Cover image for Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides

Cyclometalated Ruthenium Catalyst Enables Ortho-Selective C–H Alkylation with Secondary Alkyl Bromides

Chem, 2020, 6, 1459-1468.

Gang-Wei Wang, Matthew Wheatley, Marco Simonetti, Diego M. Cannas, Igor Larrosa

Cover image for Cyclometalated Ruthenium Catalyst Enables Ortho-Selective C–H Alkylation with Secondary Alkyl Bromides

C–H Borylation: No Need to Stop for Directions

Trends in Chemistry, 2020, 2, 957-959

Hugh C. Osborne, Alastair Durie, Christine K. Schmidt, Igor Larrosa

Palladium catalysed C–H arylation of pyrenes: access to a new class of exfoliating agents for water-based graphene dispersions

Chemical Science, 2020, 11, 2472-2478

Xavier Just-Baringo, Yuyoung Shin, Adyasha Panigrahi, Marco Zarattini, Vaiva Nagyte, Ling Zhao, Kostas Kostarelos, Cinzia Casiraghi, Igor Larrosa

Cover image for Palladium catalysed C–H arylation of pyrenes: access to a new class of exfoliating agents for water-based graphene dispersions

Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge

Nanoscale, 2020, 12, 12383-12394

Yuyoung Shin, Sandra Vranic, Xavier Just-Baringo, Sai Manoj Gali, Thomas Kisby, Yingxian Chen, Alexandra Gkoutzidou, Eric Prestat, David Beljonne, Igor Larrosa, Kostas Kostarelos, Cinzia Casiraghi

Cover image for Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge

Transition metal-free cross-dehydrogenative arylation of unactivated benzylic C–H bonds

Chemical Communications, 2020, 56, 14479-14482

Andrew R. A. Spencer, Rachel Grainger, Adyasha Panigrahi, Thomas J. Lepper, Katarzyna Bentkowska, Igor Larrosa

Cover image for Transition metal-free cross-dehydrogenative arylation of unactivated benzylic C–H bonds

meta-Selective olefination of fluoroarenes with alkynes using CO2 as a traceless directing group

Chemical Science, 2020, 11, 4204-4208

Andrew R. A. Spencer, Rishi Korde, Marc Font, Igor Larrosa

Cover image for meta-Selective olefination of fluoroarenes with alkynes using CO2 as a traceless directing group

2019

Evidence for Site-Specific Reversible Hydrogen Adsorption on Graphene by Sum-Frequency Generation Spectroscopy and Density Functional Theory

The Journal of Physical Chemistry C, 2019, 123, 42, 25883–25889

Huda AlSalem, Xavier Just-Baringo, Igor Larrosa, Umberto Monteverde, Xingxing Jiang, Yexin Feng, Sven P. K. Koehler

Cover image for Evidence for Site-Specific Reversible Hydrogen Adsorption on Graphene by Sum-Frequency Generation Spectroscopy and Density Functional Theory

Catalytic Asymmetric C–H Arylation of (η6-Arene)Chromium Complexes: Facile Access to Planar-Chiral Phosphines

ACS Catalysis, 2019, 9, 6, 5268–5278

María Batuecas, Junfei Luo, Ivana Gergelitsová, Katrina Krämer, Daniel Whitaker, Iñigo J. Vitorica-Yrezabal, Igor Larrosa

Cover image for Catalytic Asymmetric C–H Arylation of (η6-Arene)Chromium Complexes: Facile Access to Planar-Chiral Phosphines

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

ACS Catalysis, 2019, 9, 4, 2854–2865

Karl A.P. Payne, Stephen A. Marshall, Karl Fisher, Matthew J. Cliff, Diego M. Cannas, Cunyu Yan, Derren J. Heyes, David A. Parker, Igor Larrosa, David Leys

Cover image for Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

Charge-tunable graphene dispersions in water made with amphoteric pyrene derivatives

Molecular Systems Design & Engineering, 2019, 4, 503-510

Yuyoung Shin, Xavier Just-Baringo, Marco Zarattini, Liam H. Isherwood, Aliaksandr Baidak, Kostas Kostarelos, Igor Larrosa, Cinzia Casiraghi

Cover image for Charge-tunable graphene dispersions in water made with amphoteric pyrene derivatives

Decarboxylative Suzuki–Miyaura coupling of (hetero)aromatic carboxylic acids using iodine as the terminal oxidant

Chemical Communications, 2019, 2019,55, 6445-6448

Jacob M. Quibell, Guojian Duan, Gregory J. P. Perry, Igor Larrosa

Cover image for Decarboxylative Suzuki–Miyaura coupling of (hetero)aromatic carboxylic acids using iodine as the terminal oxidant

2018

Benzoate Cyclometalation Enables Oxidative Addition of Haloarenes at a Ru(II) Center

Journal of the American Chemical Society, 2018, 140, 37, 11836–11847

Marco Simonetti, Rositha Kuniyil, Stuart A. Macgregor, Igor Larrosa

Cover image for Benzoate Cyclometalation Enables Oxidative Addition of Haloarenes at a Ru(II) Center

Ag(I)–C–H Activation Enables Near-Room-Temperature Direct α-Arylation of Benzo[b]thiophenes

Journal of the American Chemical Society, 2018, 140, 30, 9638–9643

Chiara Colletto, Adyasha Panigrahi, Jaime Fernández-Casado, Igor Larrosa

Cover image for Ag(I)–C–H Activation Enables Near-Room-Temperature Direct α-Arylation of Benzo[b]thiophenes

Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals

Nature Chemistry, 2018, 10, 724–731

Marco Simonetti, Diego M. Cannas, Xavier Just-Baringo, Iñigo J. Vitorica-Yrezabal, Igor Larrosa

Cover image for Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals

Ketone C–C Bond Activation Meets the Suzuki-Miyaura Cross-coupling

Chem, 2018, 4, 1203-1204

Xavier Just-Baringo, Igor Larrosa

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Chemical Science, 2018, 9, 3860-3865

Jacob M. Quibell, Gregory J. P. Perry, Diego M. Cannas, Igor Larrosa

Cover image for Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Two prime or not two prime

Nature Catalysis, 2018, 1, 381–382

Andrew Spencer, Rocio Lopez-Rodriguez, Igor Larrosa

meta-C–H arylation of fluoroarenes via traceless directing group relay strategy

Chemical Science, 2018, 9, 7133-7137

Marc Font, Andrew R. A. Spencer, Igor Larrosa

Cover image for meta-C–H arylation of fluoroarenes via traceless directing group relay strategy

2017

A Direct Arylation‐Cyclisation Reaction for the Construction of Medium‐Sized Rings

Chemistry – A European Journal, 2017, 23, 12763-12766

Daniel Whitaker, María Batuecas, Paolo Ricci, Igor Larrosa

Cover image for A Direct Arylation‐Cyclisation Reaction for the Construction of Medium‐Sized Rings

C−H Carboxylation of Aromatic Compounds through CO2 Fixation

ChemSusChem, 2017, 10, 3317-3332

Junfei Luo, Igor Larrosa

Cover image for C−H Carboxylation of Aromatic Compounds through CO2 Fixation

Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings

Journal of the American Chemical Society, 2017, 16, 1141–1150

Gregory J. P. Perry, Jacob M. Quibell, Adyasha Panigrahi, Igor Larrosa

Cover image for Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings

Recent Progress in Decarboxylative Oxidative Cross‐Coupling for Biaryl Synthesis

European Journal of Organic Chemistry, 2017, 39, 33, 11527–11536

Gregory J. P. Perry, Igor Larrosa

Ruthenium‐Catalyzed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides

Chemistry – A European Journal, 2017, 23, 549-543

Marco Simonetti, Diego M. Cannas, Adyasha Panigrahi, Szymon Kujawa, Michal Kryjewski, Pan Xie, Igor Larrosa

Cover image for Ruthenium‐Catalyzed C−H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides

Biaryl Synthesis via C–H Bond Activation: Strategies and Methods

Advances in Organometallic Chemistry, 2017, 67, 299-399

Marco Simonetti, Diego M. Cannas, Igor Larrosa

Determination of ²H KIEs from Competition Experiments: Increased Accuracy via Isotopic Enrichment

Topics in Catalysis, 2017, 60, 589–593

Chiara Colletto, Daniel Whitaker, Igor Larrosa

Cover image for Determination of <sup>2</sup>H KIEs from Competition Experiments: Increased Accuracy via Isotopic Enrichment

Photoelectrocatalysis of Rhodamine B and Solar Hydrogen Production by TiO2 and Pd/TiO2 Catalyst Systems

Electrochimica Acta, 2017, 231,641-649

Pelin Yilmaz, Armando Marsden Lacerda, Igor Larrosa, Steve Dunn

Reaction monitoring reveals poisoning mechanism of Pd2(dba)3 and guides catalyst selection

Chemical Communications, 2017, 53, 12890-12893

Chiara Colletto, Jordi Burés, Igor Larrosa

Cover image for Reaction monitoring reveals poisoning mechanism of Pd2(dba)3 and guides catalyst selection

The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation

Chemical Communications, 2017, 53, 5584-5597

Marc Font, Jacob M. Quibell, Gregory J. P. Perry, Igor Larrosa

Cover image for The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation

2016

A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols

Chemistry - An Asian Journal, 2016, 11, 347-350

Junfei Luo, Sara Preciado, Solomon Olatokunbo Araromi, Igor Larrosa

Cover image for A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols

Ag(I)-Catalyzed C-H Activation: The Role of the Ag(I) Salt in Pd/Ag-Mediated C-H Arylation of Electron-Deficient Arenes

Journal of the American Chemical Society, 2016, 138, 27, 8384–8387

Daniel Whitaker, Jordi Burés, Igor Larrosa

Cover image for Ag(I)-Catalyzed C-H Activation: The Role of the Ag(I) Salt in Pd/Ag-Mediated C-H Arylation of Electron-Deficient Arenes

C-H activation: Good things come in threes

Nature Chemistry, 2016, 8, 1086–1088

Marco Simonetti, Igor Larrosa

Carboxylation of Phenols with CO2 at Atmospheric Pressure

Chemistry - A European Journal, 2016, 22, 6798-6802

Junfei Luo, Sara Preciado, Pan Xie, Igor Larrosa

Cover image for Carboxylation of Phenols with CO<inf>2</inf> at Atmospheric Pressure

Direct ortho-Arylation of Pyridinecarboxylic Acids: Overcoming the Deactivating Effect of sp²-Nitrogen

Organic Letters, 2016, 18, 23, 6094–6097

Adam J. S. Johnston, Kenneth B. Ling, David Sale, Nathalie Lebrasseur, Igor Larrosa

Cover image for Direct ortho-Arylation of Pyridinecarboxylic Acids: Overcoming the Deactivating Effect of sp<sup>2</sup>-Nitrogen

Room-Temperature Direct β-Arylation of Thiophenes and Benzo[b]thiophenes and Kinetic Evidence for a Heck-type Pathway

Journal of the American Chemical Society, 2016, 138, 5, 1677–1683

Chiara Colletto, Saidul Islam, Francisco Juliá-Hernández, Igor Larrosa

Cover image for Room-Temperature Direct β-Arylation of Thiophenes and Benzo[b]thiophenes and Kinetic Evidence for a Heck-type Pathway

Ru-Catalyzed C-H Arylation of Fluoroarenes with Aryl Halides

Journal of the American Chemical Society, 2016, 138, 10, 3596–3606

Marco Simonetti, Gregory J. P. Perry, Xacobe C. Cambeiro, Francisco Juliá-Hernández, Jude N. Arokianathar, Igor Larrosa

Cover image for Ru-Catalyzed C-H Arylation of Fluoroarenes with Aryl Halides

2015

Au-Catalyzed Cross-Coupling of Arenes via Double C-H Activation

Journal of the American Chemical Society, 2015, 137, 50, 15636–15639

Xacobe C. Cambeiro, Nanna Ahlsten, Igor Larrosa

Cover image for Au-Catalyzed Cross-Coupling of Arenes via Double C-H Activation

Plasmon enhanced visible light photocatalysis for TiO2 supported Pd nanoparticles

Nanoscale, 2015, 7, 12331-12335

A. M. Lacerda, I. Larrosa, S. Dunn

Cover image for Plasmon enhanced visible light photocatalysis for TiO<inf>2</inf> supported Pd nanoparticles

Salicylic acids as readily available starting materials for the synthesis of meta-substituted biaryls

Chemical Communications, 2015, 51, 3127-3130

Junfei Luo, Sara Preciado, Igor Larrosa

Cover image for Salicylic acids as readily available starting materials for the synthesis of meta-substituted biaryls

Selective and general exhaustive cross-coupling of di-chloroarenes with a deficit of nucleophiles mediated by a Pd-NHC complex

Chemical Communications, 2015, 51, 3832-3834

Benjamin J. Groombridge, Stephen M. Goldup, Igor Larrosa

Cover image for Selective and general exhaustive cross-coupling of di-chloroarenes with a deficit of nucleophiles mediated by a Pd-NHC complex

2014

An organic cation as a silver(i) analogue for the arylation of sp ² and sp³ C-H bonds with iodoarenes

Chemical Science, 2014, 5, 3509-3514

Carlos Arroniz, J. Gabriel Denis, Alan Ironmonger, Gerasimos Rassias, Igor Larrosa

Cover image for An organic cation as a silver(i) analogue for the arylation of sp <sup>2</sup> and sp<sup>3</sup> C-H bonds with iodoarenes

Overriding ortho-para selectivity via a traceless directing group relay strategy: The meta-selective arylation of phenols

Journal of the American Chemical Society, 2014, 136, 4109-12

Junfei Luo, Sara Preciado, Igor Larrosa

Cover image for Overriding ortho-para selectivity via a traceless directing group relay strategy: The meta-selective arylation of phenols

The ortho-substituent effect on the Ag-Catalysed decarboxylation of benzoic acids

Chemistry - A European Journal, 2014, 20, 16680-16687

Rachel Grainger, Josep Cornella, David C. Blakemore, Igor Larrosa, Josep M. Campanera

Cover image for The ortho-substituent effect on the Ag-Catalysed decarboxylation of benzoic acids

Tuning reactivity and site selectivity of simple arenes in C-H activation: Ortho-arylation of anisoles via arene-metal π-Complexation

Journal of the American Chemical Society, 2014, 136, 18082-18086

Paolo Ricci, Katrina Krämer, Igor Larrosa

Cover image for Tuning reactivity and site selectivity of simple arenes in C-H activation: Ortho-arylation of anisoles via arene-metal π-Complexation

2013

A silver-free system for the direct C-H auration of arenes and heteroarenes from gold chloride complexes

Catalysis Science and Technology, 2013, 3, 2892-2897(Hot Article)

Nanna Ahlsten, Gregory J. P. Perry, Xacobe C. Cambeiro, Tanya C. Boorman, Igor Larrosa

Cover image for A silver-free system for the direct C-H auration of arenes and heteroarenes from gold chloride complexes

Arene-metal π-complexation as a traceless reactivity enhancer for C-H arylation

Journal of the American Chemical Society, 2013, 135, 13258-61.

Paolo Ricci, Katrina Krämer, Xacobe C. Cambeiro, Igor Larrosa

Cover image for Arene-metal π-complexation as a traceless reactivity enhancer for C-H arylation

Direct ortho-arylation of ortho-substituted benzoic acids: Overriding Pd-catalyzed protodecarboxylation

Organic Letters, 2013, 15, 910-3

Carlos Arroniz, Alan Ironmonger, Gerry Rassias, Igor Larrosa

Cover image for Direct ortho-arylation of ortho-substituted benzoic acids: Overriding Pd-catalyzed protodecarboxylation

Metalation dictates remote regioselectivity: Ruthenium-catalyzed functionalization of meta C_Ar-H bonds

Angewandte Chemie - International Edition, 2013, 52, 11458-60

Francisco Juliá‐Hernández, Marco Simonetti, Igor Larrosa

Cover image for Metalation dictates remote regioselectivity: Ruthenium-catalyzed functionalization of meta C<sub>Ar</sub>-H bonds

On water phosphine-free palladium-catalyzed room temperature C-H arylation of indoles

Chemistry - A European Journal, 2013, 19, 15093-96

Saidul Islam, Igor Larrosa

Cover image for On water phosphine-free palladium-catalyzed room temperature C-H arylation of indoles

Redox-controlled selectivity of C-H activation in the oxidative cross-coupling of arenes

Angewandte Chemie - International Edition, 2013, 52, 1781-4 (Hot Paper)

Xacobe C. Cambeiro, Tanya C. Boorman, Pengfei Lu, Igor Larrosa

Cover image for Redox-controlled selectivity of C-H activation in the oxidative cross-coupling of arenes

2012

Decarboxylative carbon-carbon bond-forming transformations of (hetero)aromatic carboxylic acids

Synthesis, 2012, 653-76

Igor Larrosa, Josep Cornella

Cover image for Decarboxylative carbon-carbon bond-forming transformations of (hetero)aromatic carboxylic acids

Recent Advances in the C2 and C3 Regioselective Direct Arylation of Indoles

Advances in Heterocyclic Chemistry, 2012, 309-351

Nathalie Lebrasseur, Igor Larrosa

Cover image for Recent Advances in the C2 and C3 Regioselective Direct Arylation of Indoles

Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids

Organic and Biomolecular Chemistry, 2012, 10, 3172-4

Rachel Grainger, Arif Nikmal, Josep Cornella, Igor Larrosa

Cover image for Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids

Studies on the total synthesis of lactonamycin: Synthesis of the fused pentacyclic B-F ring unit

European Journal of Organic Chemistry, 2012, 107-13

Sylvain A. Jacques, Simon Michaelis, Björn Gebhardt, Andreas Blum, Nathalie Lebrasseur, Igor Larrosa, Andrew J. P. White, Anthony G. M. Barrett

2011

A novel mode of reactivity for gold(I): The decarboxylative activation of (hetero)aromatic carboxylic acids

Advanced Synthesis and Catalysis, 2011, 353, 1359-66

Josep Cornella, Martin Rosillo‐Lopez, Igor Larrosa

Cover image for A novel mode of reactivity for gold(I): The decarboxylative activation of (hetero)aromatic carboxylic acids

Carboxylic acids as traceless directing groups for formal meta-selective direct arylation

Angewandte Chemie - International Edition, 2011, 40, 9429-32

Josep Cornella, Marika Righi, Igor Larrosa

Cover image for Carboxylic acids as traceless directing groups for formal meta-selective direct arylation

Gold-mediated C–H bond functionalisation

Chemical Society Reviews, 2011, 40, 1910-25

Tanya C. Boorman, Igor Larrosa

Cover image for Gold-mediated C–H bond functionalisation

Recent Advances in the C-2 Regioselective Direct Arylation of Indoles

Progress in Heterocyclic Chemistry, 2011, 1-20

Tanya C. Boorman, Igor Larrosa

Cover image for Recent Advances in the C-2 Regioselective Direct Arylation of Indoles

Two flavors of PEPPSI-IPr: Activation and diffusion control in a single NHC-ligated Pd catalyst?

Organic Letters, 2011, 13, 146-9

Igor Larrosa, Clara Somoza, Alexandre Banquy, Stephen M. Goldup

Cover image for Two flavors of PEPPSI-IPr: Activation and diffusion control in a single NHC-ligated Pd catalyst?

2010

Decarboxylative homocoupling of (hetero)aromatic carboxylic acids

Chemical Communications, 2010, 46, 8276-8278

Josep Cornella, Hicham Lahlali, Igor Larrosa

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Gold(I)-mediated C-H activation of arenes

Journal of the American Chemical Society, 2010, 132, 5580-1

Pengfei Lu, Tanya C. Boorman, Alexandra M. Z. Slawin, Igor Larrosa

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2009

Intermolecular decarboxylative direct C-3 arylation of indoles with benzoic acids

Organic Letters, 2009, 11, 5506-9

Josep Cornella, Pengfei Lu, Igor Larrosa

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Silver-catalyzed protodecarboxylation of heteroaromatic carboxylic acids

Organic Letters, 2009, 11, 5710-3

Pengfei Lu, Carolina Sanchez, Josep Cornella, Igor Larrosa

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Stereoselective synthesis of α- And β-C-glycosides by addition of titanium enolates to glycals

Synlett, 2009, 2982-6

Pedro Romea, Fèlix Urpí, Erik Gálvez, Igor Larrosa

2008

Room temperature and phosphine free palladium catalyzed direct C-2 arylation of indoles

Journal of the American Chemical Society, 2008, 130, 2926-7

Nathalie Lebrasseur, Igor Larrosa

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Synthesis of six-membered oxygenated heterocycles through carbon-oxygen bond-forming reactions

Tetrahedron, 2008, 16, 1141–1150

Igor Larrosa, Pedro Romea, Fèlix Urpí

2006

Highly convergent three component benzyne coupling: The total synthesis of ent-clavilactone B

Journal of the American Chemical Society, 2006, 128, 14042-3

Igor Larrosa, Marianne I. Da Silva, Patricio M. Gómez, Peter Hannen, Eunjung Ko, Steven R. Lenger, Simon R. Linke, Andrew J. P. White, Donna Wilton, Anthony G. M. Barrett