Ruthenium-based catalysts are renowned for their ability to promote selective hydrogenation, oxidation, and metathesis processes, which are essential in organic synthesis and industrial applications. However, despite their widespread utility, many of the developed protocols require high reaction temperatures or light irradiation, limiting their use on delicate high-complexity substrates. We have recently developed a new highly reactive air- and moisture-stable ruthenium precatalyst - RuAqua. This new precatlayst can facilitate an array of transformations, including late-stage C(sp2)–H arylation, primary/secondary alkylation, methylation, hydrogen/deuterium exchange, C(sp3)–H oxidation, alkene isomerization and oxidative cleavage
Selected Publications:
An air- and moisture-stable ruthenium precatalyst for diverse reactivity,
Gillian McArthur, Jamie H. Docherty, Misha Deepak Hareram, James J. Douglas, Igor Larrosa*
Nature Chemistry, 2024