C-H functionalisation is a transformative strategy in organic chemistry. This approach is important because it enables the efficient construction of complex molecules without the need for pre-functionalised substrates, simplifying synthesis routes and reducing waste. By selectively activating inert C-H bonds, chemists can introduce a wide range of functional groups, facilitating the creation of pharmaceuticals, agrochemicals, and advanced materials. C-H functionalisation also enhances atom economy and reaction efficiency, aligning with sustainable chemistry goals. Its development expands the toolbox of synthetic methodologies, fostering innovation and progress in various scientific and industrial fields. While a powerful tool C-H functionalisation remains limited with biological molecules often being out of reach.
Selected Publications:
Ruthenium-Catalyzed Monoselective C–H Methylation and d3-Methylation of Arenes,
Ashley Hogg, Matthew Wheatley, Pablo Domingo-Legarda, Asier Carral-Menoyo, Naomi Cottam, Igor Larrosa*
, JACS Au, 2022
Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals,
Marco Simonetti, Diego M. Cannas, Xavier Just-Baringo, Iñigo J. Vitorica-Yrezabal, Igor Larrosa*
, Nature Chemistry, 2018
Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules
Jamie H. Docherty, Thomas M. Lister, Gillian Mcarthur, Michael T. Findlay, Pablo Domingo-Legarda, Jacob Kenyon, Shweta Choudhary and Igor Larrosa*
, Chemical Reviews, 2023