Carboxylic acids or their corresponding esters are ubiquitous in organic chemistry. Leveraging this accessibility is vital for decarboxylative functionalisation, which enables the transformation of these readily available starting materials into a wide variety of valuable products. This strategy allows for the introduction of diverse functional groups, often under mild conditions, and can simplify synthetic routes by avoiding the need for pre-functionalised substrates. Decarboxylative functionalisation also facilitates the construction of complex molecules and natural products, contributing significantly to advancements in pharmaceuticals, agrochemicals, and material science.
Selected Publications:
Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings
Gregory J. P. Perry, Jacob M. Quibell, Adyasha Panigrahi, Igor Larrosa* JACS, 2017 Transition-metal-free decarboxylative bromination of aromatic carboxylic acids
Jacob M. Quibell, Gregory J. P. Perry, Diego M. Cannas, Igor Larrosa* Chemical Science, 2018 Silver-catalyzed protodecarboxylation of heteroaromatic carboxylic acids
Pengfei Lu, Carolina Sanchez, Josep Cornella, Igor Larrosa*
Organic Letters 2009
Recent Progress in Decarboxylative Oxidative CrossâCoupling for Biaryl Synthesis
Gregory J. P. Perry, Igor Larrosa*
European Journal of Organic Chemistry, 2017