Skin
Chronic wounds: Treatment
Growth factors for dermal wounds
- TGF-α (member of EGF family)
- Potent keratinocyte mitogen and motogen
- Released at site of injury
- Not enough experimental data yet
- FGF
- Causes proliferation of keratinocytes and fibroblasts
- Animal studies: FGF-2 caused reepithelialisation of wounds and enhanced healing of chronic pressure sores
- Large pharmaceutical trials inconclusive
- PDGF (AB-platelets and BB-macrophages and epidermal cells in response to injury)
- Application to wounds led to more rapid healing
- Clinical trials for diabetic foot ulcers encouraging
- PDGF BB was first growth factor to be approved by FDA
- TGF-β family:
- Chemotactic for macrophages
- Stimulates production of collagen 1 and fibronectin
- 1 and 2 stimulates wound healing in animals
- Human trials - TGFβ2 useful for venous stasis ulcers