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83 A Chiral 19F NMR Reporter of Foldamer Conformation in Bilayers.

Wang, S.; della Sala, F.; Cliff, M. J.; Whitehead, G. F. S.; Vitórica-Yrezábal, I. J.; Webb, S. J.

J. Am. Chem. Soc., 2022, in press

82 Enzymatic elaboration of oxime-linked glycoconjugates in solution and on liposomes.

Silva, J.; Spiess, R.; Marchesi, A.; Flitsch, S. L.; Gough, J. E.; Webb, S. J.

J. Mater. Chem. B, 2022, 10, 5016-5027.

81 a-Amino-iso-butyric acid foldamers terminated with rhodium(I) N-heterocyclic carbene catalysts.

Tilly, D. P.; Cullen, W.; Zhong, H.; Jamagne, R.; Vitórica-Yrezábal, I.; Webb, S. J.

Chem. Eur. J., 2022, 28, e202104293.


80 Effect of varying substituent on the colour change transitions of diacetylene pigments.

Wrackmeyer, M.; O'Rourke, A. P.; Pugh, T.; Turner, M. L.; Webb, S. J.

Dyes Pigments, 2021, 192, 109397.

79 Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers.

della Sala, F.; Tilly, D. P.; Webb, S. J.

New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications 2021, M. J. M. Abadie (eds.), Springer Nature Switzerland AG, pp. 1-24.

78 Insight into mechanism of action and peptide-membrane interactions of Aib-rich peptides: multi-technique experimental and theoretical analysis.

Lizio, M. G.; Campana, M.; De Poli, M.; Jefferies, D. F.; Cullen, W.; Andrushchenko, V.; Chmel, N. P.; Bour, P.; Khalid, S.; Clayden, J.; Blanch, E.; Rodger, A; Webb, S. J.

ChemBioChem 2021, 22, 1656-1667.


77 Transmembrane Ion Channels Formed by a Star of David [2]Catenane and a Molecular Pentafoil Knot.

August, D. P.; Borsley, Cockroft S. L.; della Sala, F.; Leigh, D. A.; Webb, S. J.

J. Am. Chem. Soc. 2020, 142, 18859-18865.

76 Photo-dissociation of self-assembled (anthracene-2-carbonyl)amino acid hydrogels.

Chivers, P. R. A.; Dookie, R. S.; Gough, J. E.; Webb S. J.

Chem. Commun. 2020, 56, 13792-13795.

75 Switchable foldamer ion channels with antibacterial activity.

Peters, A. D.; Borsley, S.; della Sala, F.; Cairns-Gibson, D. F.; Leonidou, M.; Clayden, J.; Whitehead, G. F. S.; Vitórica-Yrezábal, I. J.; Takano, E.; Burthem, J.; Cockroft S. L.; Webb, S. J.

Chem. Sci. 2020, 11, 7023-7030.

74 Molecular recognition by Zn(II)-capped dynamic foldamers.

Eccles, N.; della Sala, F.; Le Bailly, B. A. F.; Whitehead, G. F. S.; Clayden, J.; Webb S. J.

ChemistryOpen 2020, 9, 338-345.


73 High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI.

Fallows, T. W.; McGrath, A. J.; Silva, J.; McAdams, S. G.; Marchesi, A.; Tuna, F.; Flitsch, S. L.; Tilley, R. D.; Webb S. J.

Nanoscale Adv. 2019, 1, 3597-3606.

72 Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers.

Eccles, N.; Le Bailly, B. A. F.; della Sala, F.; Vitórica-Yrezábal, I. J.; Clayden, J.; Webb S. J.

Chem. Commun. 2019, 55, 9331-9334.

71 Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in E. coli.

Cummings, M.; Peters, A. D.; Whitehead, G. F. S.; Menon, B. R. K.; Micklefield, J.; Webb, S. J.; Takano, E.

PLoS Biol. 2019, 17, e3000347.

70 Dual action CXCR4-targeting liposomes in leukemia: function blocking and drug delivery.

McCallion, C.; Peters, A. D.; Booth, A.; Rees-Unwin, K.; Adams, J. A.; Rahi, R.; Pluen, A.; Hutchinson, C.; Webb, S. J.; Burthem, J.

Blood Adv. 2019, 3, 2069-2081.


69 Synthesis and biological activity of a CXCR4-targeting bis(cyclam) lipid.

Peters, A. D.; McCallion, C.; Booth, A.; Adams, J. A.; Rees-Unwin, K.; Pluen, A.; Burthem, J.; Webb, S. J.

Org. Biomol. Chem. 2018, 16, 6479-6490.

68 Bis-pyrene probes of foldamer conformation in solution and in phospholipid bilayers.

Lister, F. G. A.; Eccles, N.; Pike, S. J.; Brown, R. A.; Whitehead, G. F. S.; Raftery, J.; Webb, S. J.; Clayden, J.

Chem. Sci. 2018, 9, 6860-6870.

67 Optically Active Vibrational Spectroscopy of alpha-Aminoisobutyric Acid Foldamers in Organic Solvents and Phospholipid Bilayers.

Lizio, M. G.; Andrushchenko, V.; Pike, S. J.; Peters, A. D.; Whitehead, G. F. S.; Vitórica-Yrezábal, I. J.; Mutter, S. T.; Clayden, J.; Bour, P.; Blanch, E. W.; Webb, S. J.

Chem. Eur. J. 2018, 24, 9399-9408.

This article also appears in: "Hot Topic: Membranes".

66 ‘One-pot’ sequential enzymatic modification of synthetic glycolipids in vesicle membranes.

Craven, F. L.; Silva, J.; Segarra-Maset, M. D.; Huang, K.; Both, P.; Gough, J. E.; Flitsch, S. L.; Webb, S. J.

Chem. Comm. 2018, 54, 1347-1350.

65 The Role of Terminal Functionality in the Membrane and Antibacterial Activity of Peptaibol-Mimetic Aib Foldamers.

Adam, C.; Peters, A. D.; Lizio, M. G.; Whitehead, G. F. S.; Diemer, V.; Cooper, J. A.; Cockroft, S. L.; Clayden, J.; Webb, S. J.

Chem. Eur. J. 2018, 24, 2249–2256.

Selected as a "Hot Paper".


64 Targeting nanoparticles to chronic lymphocytic leukaemia: exploiting the properties of CXCR4.

McCallion, C.; Booth, A.; Adams, J.; Peters, A.; Webb, S.; Burthem, J.

EMJ Hematol. 2017, 5, 63-65.

63 Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers.

Diemer, V.; Maury, J.; Le Bailly, B. A. F.; Webb, S. J.; Clayden, J.

Chem. Commun. 2017, 53, 10768-10771.

62 Aqueous dispersions of nanostructures formed through the self-assembly of iminolipids with exchangeable hydrophobic termini.

Li, W.; McManus, D.; Liu, H.; Casiraghi C.; Webb, S.J.

Phys. Chem. Chem. Phys. 2017, 19, 17036-17043

Selected as a "2017 PCCP HOT Article".

61 A Bifunctional Spin Label for Ligand Recognition on Surfaces.

Hollas, M. A.; Webb, S. J.; Flitsch, S. L.; Fielding, A. J.

Angew. Chem. Intl. Ed. 2017, 56, 9449–9453.

60 A tendril perversion in a helical oligomer: trapping and characterizing a screw-sense reversal.

Tomsett, M.; Maffucci, I.; Le Bailly, B. A. F.; Byrne, L.; Bijvoets, S.; Lizio, M. G.; Raftery, J.; Butts, C. P.; Webb, S. J.; Contini, A.; Clayden, J.

Chem. Sci. 2017, 8, 3007-3018.

59 Ligand-modulated conformational switching in a fully synthetic membrane-bound receptor.

Lister, F. G. A.; Le Bailly, B. A. F.; Webb, S. J.; Clayden, J.

Nature Chem. 2017, 9, 420–425

Springer Nature SharedIt link:

News & Views in: "Transmembrane Signalling: Membrane messengers" Scott L. Cockroft, Nature Chem., 2017, 9, 406-407.

Nature Chemistry editorial: "Sending a message to the other side" Nature Chem., 2017, 9, 403.

Press coverage in 8 news outlets.

58 Magnetophoretic Behavior of 3T3 Cells Incubated with Saccharide-Coated MNPs.

Fallows, T.W.; Coxon, T.P.; Gough, J.E.; Webb, S.J.

MRS Advances 2017, 2, 1279-1284.


57 Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer.

De Poli, M.; Zawodny, W.; Quinonero, O.; Lorch, M.; Webb, S.J.; Clayden, J.

Science 2016, 352, 575-580.

Commentary in: "Light flips a membrane-embedded helix" C. M. Thiele and A. S. Ulrich, Science, 2016, 352, 520.

Press coverage in 12 news outlets.

56 Length-dependent formation of transmembrane pores by 310 helical Aib foldamers.

Jones, J.E.; Diemer, V.; Adam, C.; Raftery, J.; Ruscoe, R.E.; Sengel, J.T.; Wallace, M.I.; Bader, A.; Cockroft, S.L.; Clayden, J.; Webb, S.J.

J. Am. Chem Soc. 2016, 138, 688–695.

55 A modular self-assembly approach to functionalised ß-sheet peptide hydrogel biomaterials.

King, P. J. S.; Lizio, M. G.; Booth, A.; Collins, R. F.; Gough, J. E.; Miller, A. F.; Webb, S.J.

Soft Matter 2016, 12, 1915-1923.

Free to view (Open Access)


54 A versatile approach towards multivalent saccharide displays on magnetic nanoparticles and phospholipid vesicles.

Coxon, T. P.; Fallows, T. W.; Gough J. E.; Webb, S.J.

Org. Biomol. Chem. 2015, 13 10751–10761.

Invited submission for “Multivalent Biomolecular Recognition” web-themed issue.

Free to view (Open Access)

53 Helical peptaibol mimics are better ionophores when racemic than when enantiopure.

Pike, S.J.; Jones, J.E.; Raftery, J.; Clayden, J.; Webb, S.J.

Org. Biomol. Chem. 2015, 13, 9580-9584.

Free to view (Open Access)

52 Conformational switching of a foldamer in a multi-component system by pH-filtered selection between competing non-covalent interactions.

Brioche, J.; Pike, S.J.; Tshepelevitsh, S.; Leito, I.; Morris, G.A.; Webb, S.J.; Clayden, J.

J. Am. Chem Soc. 2015, 137, 6680–6691

Selected as a JACS "Spotlight" article in May 2015.

Free to view (Open Access)

51 Abstracts of the UK-Russia Researcher Links Workshop: Extracellular vesicles - mechanisms of biogenesis and roles in disease pathogenesis. Magnetic nanoparticles for drug delivery, smart biomaterials and other applications

Pintre, I.C.; Webb, S.J.

J. Extracell. Vesicles 2015, 4, 28165. DOI:10.3402/jev.v4.28165

50 Release of proteins and enzymes from vesicular compartments by alternating magnetic fields.

Booth, A.; Pintre, I.C.; Lin, Y.; Gough J.; Webb, S.J.

Phys. Chem. Chem. Phys. 2015, 17, 15579-15588.

Invited submission for “Chemical compartmentalisation by membranes: from biological mechanism to biomimetic applications” special issue.

Free to view (Open Access)

49 Participation of Non-Aminoisobutyric Acid (Aib) Residues in the 310 Helical Conformation of Aib-Rich Foldamers: A Solid State Study.

Pike, S.J.; Boddaert, T.; Raftery, J.; Webb, S.J.; Clayden, J.

New J. Chem. 2015, 39, 3288-3294.


48 Sialylation of lactosyl lipids in membrane microdomains by T. cruzi trans-sialidase.

Noble, GT; Craven, FL; Segarra-Maset, MD; Reyes Martínez, JE; Šardzík, R; Flitsch, SL; Webb, SJ

Org. Biomol. Chem. 2014, 12, 9272-9278.

Free to view (Open Access)

47 Designing Foldamer-Foldamer Interactions in Solution: The Roles of Helix Length and Terminus Functionality in Promoting the Self-Association of Aminoisobutyric Acid Oligomers.

Pike, S.J.; Diemer, V.; Raftery, J.; Webb, S.J.; Clayden, J.

Chem. Eur. J. 2014, 20 15981–15990.

46 Targeting of a magnetic bionanomaterial to HepG2 human hepatocellular carcinoma cells using a galactose terminated lipid.

Booth, A.; Coxon, T.; Gough, J.E.; Webb, S.J..

MRS Proceedings 2014, 1688, mrss14-1688-y05-14.

45 Catechol-hydrazone conjugates for the rapid functionalization of magnetite nanoparticles with cell targeting groups.

Coxon, T.; Almond, A.; Gough, J.E.; Webb, S.J..

MRS Proceedings 2014, 1688, mrss14-1688-y08-13.

44 Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs.

Pike, S.J.; Raftery, J.; Webb, S.J.; Clayden, J.

Org. Biomol. Chem. 2014, 12, 4124-4131.

43 Fructose controlled ionophoric activity of a cholate–boronic acid.

Brown, J.R.D.; Pintre, I.C.; Webb, S.J.

Org. Biomol. Chem. 2014, 12, 2576-2583

Selected as a “hot” article in March 2014.

Free to view (Open Access)


42 Binding and Reactivity at Bilayer Membranes.

Pintre, I.C.; Webb, S.J.

Adv. Phys. Org. Chem. 2013, 47, 129-183

Invited submission

41 End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching.

Brown, R.A.; Diemer, V.; Webb, S.J.; Clayden, J.

Nature Chem. 2013, 5, 853-860

40 Supramolecular approaches to combining membrane transport with adhesion.

Webb, S.J.

Acc. Chem. Res 2013, 46, 2878–2887

Invited submission for “Transport Across Membranes” special issue.

Free to view (Open Access)

39 Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers.

Pike S.J.; De Poli, M.; Zawodny, W.; Raftery, J.; Webb, S.J.; Clayden, J.

Org. Biomol. Chem. 2013, 11, 3168-3176

38 Spatially-controlled apoptosis induced by released nickel(II) within a magnetically responsive nanostructured biomaterial.

de Cogan, F.; A. Booth, A.; Gough, J.E.; Webb, S.J.

Soft Matter 2013, 9, 2245-2253

37 Interfacing biodegradable molecular hydrogels with liquid crystals.

Lin, I-H.; Birchall, L.S.; Hodson, N.; Ulijn, R.V.; Webb, S.J.

Soft Matter 2013, 9, 1188-1193


36 Accelerated enzymatic galactosylation of N-acetylglucosaminolipids in lipid microdomains.

Noble, GT; Craven, FL; Voglmeir, J; Šardzík, R; Flitsch, SL; Webb, SJ

J. Am. Chem. Soc. 2012, 134, 13010-13017

Selected as a JACS "Spotlight" article in Sept. 2012.

35 Sequence/structure relationships in aromatic dipeptide hydrogels formed under thermodynamic control by enzyme-assisted self-assembly.

Hughes, M; Frederix, PWJM; Raeburn, J; Birchall, LS; Sadownik, J; Coomer, FC; Lin, I-H; Cussen, EJ; Hunt, NT; Tuttle, T; Webb, SJ; Adams, DJ; Ulijn, RV.

Soft Matter 2012, 8, 5595-5602

34 Supramolecular Chemistry of Membranes.

Noble, GT; Mart, RJ; Liem, KP; Webb, SJ

in "Supramolecular Chemistry: From Molecules to Nanomaterials"
edited by Jonathan W. Steed and Philip A. Gale, John Wiley & Sons, Chichester
2012, pp. 1731-1750


33 Conversion of Magnetic Impulses into Cellular Responses by
Self-Assembled Nanoparticle–Vesicle Hydrogels

de Cogan, F; Booth, A; Gough, JE; Webb, SJ

Angew. Chem. Intl. Ed. Engl. 2011, 50, 12290-12293

32 Adhesive interactions between cells and biotinylated phospholipid vesicles
in alginate: towards new responsive biomaterials.

de Cogan, F; Gough, JE; Webb, SJ

J. Mater. Sci.-Mater. M. 2011, 22, 1405.

31 Targeted drug delivery in vitro

Leng, F; Webb, SJ; Gough JE

Eur. Cell. Mater. 2011, 22, 17.

30 Palladium(II)-mediated assembly of biotinylated ion channels.

Wilson, CP; Boglio, C; Ma, L; Cockroft, SL; Webb, SJ

Chem. Eur. J. 2011, 17, 3465-3473.

29 Pd(II)-mediated assembly of porphyrin channels in bilayer membranes.

Devi, U; Brown, JRD; Almond, A; Webb, SJ

Langmuir 2011, 27, 1448-1456.

Invited submission for “Supramolecular Chemistry at Interfaces” special issue.


28 Preparation of aminoethyl glycosides for glycoconjugation.

Šardzík, R; Noble, GT; Weissenborn, MJ; Martin, A; Webb, SJ; Flitsch, SL.

Beilstein J. Org. Chem. 2010, 6, doi:10.3762/bjoc.6.81

27 Enhancing cell culture in magnetic vesicle gels.

Leng, F; Gough, JE; Webb, SJ.

MRS Proceedings 2010, 1272, 1272-PP07-02.

26 The effect of multivalent binding on the lateral phase separation of adhesive lipids.

Liem, KP; Noble, GT; Flitsch, SL; Webb, SJ.

Faraday Discuss. 2010, 145, 219-233.


25 Novel Gelation System For Fabricating 3-D Structures via Ink Jet Printing.

Saunders, RE; Liem, KP; Mart, RJ; Webb, SJ; Derby B.

MRS Proceedings 2009, 1239, 1239-VV06-10.

24 Assessing the cluster glycoside effect during the binding of concanavalin A to mannosylated artificial lipid rafts.

Noble, GT; Liem, KP; Flitsch, SL; Webb, SJ.

Org. Biomol Chem. 2009, 7, 5245-5254.

23 Magnetically-Controlled Release from Hydrogel-Supported Vesicle Assemblies.

Mart, RJ; Liem, KP; Webb, SJ.

Chem. Commun. 2009, 2287-2289.

Selected as a “hot” article (, highlighted in Chem. Technol. 2009, 6, T36 and in Chemistry World, 2009, 6, 30.

22 Creating functional vesicle assemblies from vesicles and nanoparticles.

Mart, RJ; Liem, KP; Webb, SJ.

Pharm. Res., 2009, 26, 1701-1710.

Invited submission for “Biomaterials in Drug Delivery” special issue.


21 Palladium(II)-gated ion channels.

Wilson, CP; Webb, SJ.

Chem. Commun. 2008, 4007-4009.

Highlighted in a commentary in Chem. Biol., 2008, 3, B66.

20 Bioinspired organic chemistry.

Mart, RJ; Webb, SJ.

Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2008, 104, 370-393.

Highlighted online in Chemical Biology (Research Articles), 2008, Issue 9.

19 A combined SPS-LCD sensor for screening protease specificity.

Birchall, LS; Ulijn, RV; Webb, SJ.

Chem. Commun. 2008, 2861-2863.

Selected as a “hot” article ( and for the inside front cover illustration.

18 Enzyme-responsive hydrogel particles for the controlled release of proteins: designing peptide actuators to match payload.

Thornton, PD; Mart, RJ; Webb, SJ; Ulijn, RV.

Soft Matter, 2008, 4, 821-827.

Selected for the back cover illustration (right).


17 Magnetic assembly and patterning of vesicle/nanoparticle aggregates.

Liem, KP; Mart, RJ; Webb, SJ.

J. Am. Chem. Soc. 2007, 129, 12080-12081.

16 Bioinspired organic chemistry.

Webb, SJ.

Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2007, 103, 392-415.

15 Vesicle aggregation by multivalent ligands: relating crosslinking ability to surface affinity.

Wang, X; Mart, RJ; Webb, SJ.

Org. Biomol. Chem., 2007, 5 2498-2505.

14 Transmission of binding information across lipid bilayers.

Dijkstra, HP; Hutchinson, JJ; Hunter, CA; Qin, H; Tomas, S; Webb, SJ; Williams, NH.

Chem. Eur. J., 2007, 13 7215-7222.


13 The effect of receptor clustering on vesicle-vesicle adhesion.

Mart, RJ; Liem, KP; Wang, X; Webb, SJ.

J. Am. Chem. Soc. 2006, 128, 14462-14463.

12 Lipid fluorination enables phase separation from fluid phospholipid bilayers.

Webb, SJ; Greenaway, K; Bayati, M; Trembleau, L.

Org. Biomol. Chem. 2006, 4 2399-2407.

11 Bioinspired organic chemistry.

Webb, SJ.

Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2006, 102 377-400.

10 Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins.

Walton, J; Tiddy, GJT; Webb, SJ.

Tetrahedron Lett. 2006, 47, 737-741.


09 Membrane composition determines the fate of aggregated vesicles.

Webb, SJ; Trembleau, L; Mart, RJ; Wang, X.

Org. Biomol. Chem. 2005, 3 3615-3617.

Post-doctoral and PhD research 1998-2003

08 Cooperative binding at lipid bilayer membrane surfaces.

Doyle, EL; Hunter, CA; Phillips, HC; Webb, SJ; Williams. NH.

J. Am. Chem. Soc, 2003, 125, 4593-4599.

07 Transmembrane signalling.

Barton, P; Hunter, CA; Potter, TJ; Webb, SJ; Williams, NH.

Angew. Chem. Intl. Ed. Engl. 2002, 41 3878-3881.

06 Axial coordination chemistry of metalloporphyrins.

Sanders, JKM; Bampos, N; Clyde-Watson, Z; Darling, SL; Hawley, JC; Kim, H-J; Mak, CC; Webb, SJ.

Porphyrin Handbook, Ed. Kadish, KM; Smith, KM; Guilard, R, Chapter 3, pp 1-48. 2000.

05 A tin(IV)-ruthenium(II)-tin(IV) cyclic porphyrin trimer with replaceable chiral linings.

Webb, SJ; Sanders, JKM.

Inorg. Chem., 2000, 39, 5920-5929.

04 Synthesis and recognition properties of a ruthenium(II)-bis(zinc) cyclic porphyrin trimer.

Webb, SJ; Sanders, JKM.

Inorg. Chem., 2000, 39, 5912-5919.

03 NMR studies of molecular recognition by metalloporphyrins.

Bampos, N; Clyde-Watson, Z; Hawley, JC; Mak, A; Vidal-Ferran, Webb, SJ; Sanders, JKM.

NATO ASI Ser., Ser. C, 526 (NMR in Supramolecular Chemistry), 1999, 37-44.

02 Ruthenium Complexes of a simple tridentate ligand bearing two "distal" pyridine bases.

Redmore, SM; Rickard, CEF; Webb, SJ; Wright, LJ.

Inorg. Chem., 1997, 36, 4743-4748.

01 Stereospecific templated synthesis of a triruthenium butadiyne-linked cyclic porphyrin trimer.

Marvaud, V; Vidal-Ferran, A; Webb, SJ; Sanders, JKM.

J. Chem. Soc. Dalton Trans., 1997 985-990.