Peripheral Nerve
Injury and Regeneration - Wallerian Degeneration
- Following transection of a peripheral nerve, in the distal nerve stump Wallerian degeneration occurs
- Characterised by
- Macrophage recruitment
- Degradation of both the axonal and myelin components
- Proliferation of endoneurial fibroblasts and resident SC population which align with the original basal lamina to form bands of Bungner