Peripheral Nerve

Injury and Regeneration - Wallerian Degeneration

  • Following transection of a peripheral nerve, in the distal nerve stump Wallerian degeneration occurs
  • Characterised by
    • Macrophage recruitment
    • Degradation of both the axonal and myelin components
    • Proliferation of endoneurial fibroblasts and resident SC population which align with the original basal lamina to form bands of Bungner

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