Peripheral Nerve

Structure

  • Individual nerve fibres are supported by a collagen rich endoneurium
  • Fibres are grouped in bundles or fascicles which are contained within the perineurium
  • Perineurium is a specialised tissue composed of flattened perineurial cells, alternating with layers of collagen
    • Maintains the homeostasis of the endoneurial fluid surrounding myelinated and unmyelinated fibres and provides a barrier to diffusion
  • Fasicles are embedded in connective tissue, which in its outer layers condenses to form the epineurium or nerve sheath
  • Each PN may contain one or multiple fascicles
  • Each PN has an extensive blood supply composed of interconnecting epineurial, perineurial and endoneurial plexuses which link with extrinsic regional vessels

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