Liver

Extracorporeal hepatocyte based bioreactors

Hollow fibre bioreactor

  • 1992 (Sussman)
  • Hepatoma cell line of human origin
  • cellulose acetate hollow fibre containing 200g cells on the outer surface

Also:

  • Cells embedded in a collagen hydrogel
  • Injected into hollow fibres
  • Collagen gel contracts in presence of cells
  • Leaves a lumen for perfusion of media and patient plasma

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