Liver
Extracorporeal hepatocyte based bioreactors
Hollow fibre bioreactor
- 1992 (Sussman)
- Hepatoma cell line of human origin
- cellulose acetate hollow fibre containing 200g cells on the outer surface
Also:
- Cells embedded in a collagen hydrogel
- Injected into hollow fibres
- Collagen gel contracts in presence of cells
- Leaves a lumen for perfusion of media and patient plasma