Liver
Extracorporeal hepatocyte based bioreactors
Hepatocyte suspensions
- 1987 (Matsumura):
- Hemodialysis principle
- Rabbit hepatocytes
- Dialysis for 5 hours over 3 days
- Appeared successful but no further development
- 1989 (Margulis)
- 20ml capsule
- 40x106 porcine hepatocytes
- Activated charcoal
- 37% mortality in patients tested compared to 59% in control