Liver

Extracorporeal hepatocyte based bioreactors

Hepatocyte suspensions

  • 1987 (Matsumura):
    • Hemodialysis principle
    • Rabbit hepatocytes
    • Dialysis for 5 hours over 3 days
    • Appeared successful but no further development
  • 1989 (Margulis)
    • 20ml capsule
    • 40x106 porcine hepatocytes
    • Activated charcoal
    • 37% mortality in patients tested compared to 59% in control

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