Ischemic and Hypoxic Injury
Irreversible Cell Injury
Cell membrane damage is central factor in pathogenesis of irreversible cell injury
- Progressive loss of phospholipids
- Increased degradation
- Decreased synthesis
- Cytoskeletal alterations
- Activation of proteases
- Damage to cytoskeletal-membrane connections
- Physical effects of cell swelling
- Free radical induced injury
- Lipid breakdown products