Ischemic and Hypoxic Injury
Reversible Cell Injury
- Aerobic respiration - oxidative phosphorylation by mitochondria
- Generation of ATP slows/stops
- Glycogen depletion due to increase in anaerobic glycolysis - maintain's energy by making ATP from glycogen
- Glycolysis results in formation of lactic acid --> decrease in pH
- Cellular swelling: due to increase in Na and efflux of K (due to decrease in Na pump activity), this results in gain in water
- Detachment of ribosomes - disruption of energy dependent interaction
- Myelin figures - derived from plasma and organelle membranes
All are reversible if oxygen is restored