Thrombogenesis
Alterations in normal blood flow
Contribute to development of arterial and cardiac thrombi
Stasis (sluggish blood flow) contributes to venous thrombosis
Stasis and turbulence (causing countercurrents and local pockets of stasis) provide 4 important dimensions:
- Disrupt laminar flow bringing platelets in contact with endothelium
- Prevent dilution by fresh flow of blood and hepatic clearance of activated coagulation factors
- Retard the in-flow of inhibitors of clotting factors and permit build up of thrombi
- Turbulence may damage the endothelium favouring platelet and fibrin
deposition while at the same time reducing the local release of
fibrinolysis factors