Our research concerns the development of novel techniques
in high resolution NMR spectroscopy, and their application to problems in
chemistry, biochemistry, and medicine. NMR is uniquely flexible, allowing great
scope for ingenuity in modifying experiments to increase the amount of chemical
information available from spectra. Multidimensional NMR methods can allow
detailed structure determination for molecules as large as proteins, while
recent advances in technique and instrumentation allow the non-invasive
measurement of localised proton spectra of metabolites in human beings. Despite
fifty years of development in both spectrometer hardware and experimental
techniques, the pace of change shows no sign of slackening: NMR methods
continue both to expand their range of application and to improve the ease with
which they can be used to probe chemical, biochemical and biological
structures.
Manchester is fortunate in being one of the best-equipped
NMR research centres in the country, with eleven superconducting spectrometers
in Chemistry alone. We are currently in the process of upgrading the NMR
equipment, with the aid of a recent �1M grant from the EPSRC. In the Medical
School there are first-class facilities for magnetic
resonance imaging (MRI), with both whole-body and high-field small-bore
systems. The School of Chemistry also hosts the national multi-frequency CW EPR
service.
Among current and recent projects in NMR research are work
on diffusion-ordered spectroscopy (DOSY), automated shimming methods, development
of stabler NMR spectrometer hardware, and reference
deconvolution methods for improved data processing, along with the use of multi-dimensional NMR methods for the determination
of complex structures, and the analysis of magnetization transfer contrast
phenomena in magnetic resonance imaging.
Further information
EPSRC final reports:
Please send any comments or questions about these pages to:
g.a.morris@ manchester.ac.uk
Most recent revision 15th April 2007