The Morris Research Group

Research in Nuclear Magnetic Resonance


 

Instrumental Developments


Most modern NMR methods, including 2D and 3D NMR, DOSY and difference spectroscopy, are critically dependent on the stability and reproducibility of the signals that NMR spectrometers produce. In many experiments, for example NOE difference spectroscopy and HMBC, the sensitivity of the technique is generally limited not by the intrinsic signal-to-noise ratio of the instrument, but by its stability. The limiting factor is the ability to distinguish between the signals of interest and a background of unwanted signals, rather than a background of random noise. Our earlier work successfully identified two of the main sources of instability in modern spectrometers (low-level mains frequency modulation of magnetic field and radiofrequency, and the temperature sensitivity of the phases of radiofrequency signals in the spectrometer console), and we are now investigating methods for suppressing and/or compensating these effects.

 


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Please send any comments or questions about these pages to:
g.a.morris@manchester.ac.uk

Most recent revision 15th April 2007