Extracellular matrix
GAGs
Heparan sulphate:
Hyaluronan
| GAG | Localisation | Comments |
|---|---|---|
| Hyaluronan | Synovial fluid, vitreous humor, ECM of loose conn. tiss. | Large polymers, shock absorbing |
| Chondroitin sulphate | Cartilage, bone, heart valves | Most abundant GAG |
| Heparan sulphate | BMs, cell surfaces | Higher acetylated glucosamine than heparin |
| Heparin | Intracellular granules in mast cells, lines arteries of lungs, liver and skin | More sulphated than heparan sulphates |
| Dermatan sulphate | Skin, blood vessels, heart valves | |
| Keratan sulphate | Cornea, bone, cartilage aggregated with chondroitin suphates |
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Useful Links:
Lectures:
- Year 1:
- Cell Biology
- Year 2:
- Tissue Interactions and Biocompatibility
- Year 3/4:
- Tissue Engineering