Cell Death

Apoptosis

Cytochrome C


Procaspase aggregation and activation can be triggered from within the cell

Mitochondria are stimulated to release cytochrome c, an electron carrier protein

  • Binds and activates cytosolic adaptor protein Apaf-1
  • This binds and activates procaspase 9
  • Caspase cascade is triggered

Bcl-2 can block the release of cytochrome c

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