Apoptosis
Caspases
ICE family of proteases known as Caspases, of which there
are approximately 14 known
- Protease activity of caspases can activate other caspases
- Cleave target proteins at specific aspartic acids
- Have cysteine at their active site
- Synthesised as procaspases
| CASPASE |
OTHER NAME |
SUBSTRATES |
| Caspase 1 |
ICE, CED-3 |
Actin |
| Caspase 2 |
Nedd2, ICH-1 |
pNEDD2, PARP |
| Caspase 3 |
CPP32, Yama, apopain |
PARP, Bcl-2, Actin |
| Caspase 4 |
ICErelII, TX, ICH-2 |
pICE, PARP |
| Caspase 5 |
ICErelIII, TY, ICH-3 |
MM
|
| Caspase 6 |
Mch2 |
PARP, lamin |