Pathogens 3: Parasites

T Cells

Fundamental to immune development

Different T cells effective against different stages of infection

  • CD4+: blood stage Plasmodium yoelli
  • CD8+: liver stage Plasmodium berghei:
  • Secrete IFNγ:inhibits multiplication of parasites in hepatocytes

    Destroys infected hepatocytes

  • Th1: Intracellular parasites
  • Th2: Extracellular parasites

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