Haemocompatibility and thrombogenicity

Heparin releasing systems

Temperature dependent swelling of materials such as poly(NiPAAm)

  • Allows hydrophilic heparin to be loaded into the polymer coating at rt
  • At physiologic temperatures, coating collapses
  • Heparin is slowly released by diffusion

Intravenous polyurethane catheters in a canine model resulted in significant reduction in thrombus formation


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