Haemocompatibility and thrombogenicity

Platelet aggregation

1. Release of dense granule ADP
2. Formation of thrombin
3. Generation of thromboxane A₂

Platelet stimulation causes activation of the GPIIb/IIIa receptors

Bind plasma proteins e.g fibrinogen causing bridging together

Thrombin binds platelets and causes:

1. Platelet activation
2. Produce more thrombin
3. Stimulate ADP release and thromboxane A₂
4. Stimulate formation of fibrin which stabilises the thrombus

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