Batch Monitoring and Control

Barry Lennox


This worked has involved the application of model predictive control and multivariate statistical techniques to both monitor and control batch processes. This work has led to some of the first real-time applications of advanced batch control techniques in the pharmaceutical industry.


Batch Monitoring

Marjanovic, O, Lennox, B., Sandoz, D and Smith, K. (2006), ‘Real-time monitoring of an industrial batch process’, Computers and Chemical Engineering, 30 (10-12), 1476-1481

Lennox, B., Kipling, K., Glassey, J., and Montague, G., (2002), ‘Automated production support for the bioprocess industry’, Biotechnology Progress, 18 (2), 269-275

Lennox, B., Hiden, H.G., Montague, G.A., Kornfeld, G. and Goulding, P.R., (2001), ‘Process monitoring of an industrial fed-batch fermentation’, Biotechnology and Bioengineering, 74 (2), 125-135


Marjanovic, O, Wu, L and Lennox, B, (2008), ‘Statistical process control of bioreactors: a comparison’, Control 2008, Manchester, UK

Marjanovic, O. and Lennox, B., (2005), ‘Statistical process monitoring of industrial batch processes’, IFPAC, Washington DC

Lennox, B., Marjanovic, O., Lovett, D. and Sandoz, D., (2004), ‘Exploiting multivariate statistics in industrial fermentation supervision’, IFPAC 2004, Washington DC

Marjanovic, O., Smith, K.J. and Lennox, B, (2004), ‘Statistical Monitoring of Industrial Batch Processes’, World Batch Forum European Conference, Belgium


Batch End-point Prediction

Lennox, B., Sandberg, E. and Marjanovic, O., (2003), ‘Recent experiences in the application of PLS in the steel industry’, PLS’03, Lisbon


Batch Control

Zhang, H. and Lennox, B., (2003), ‘Integrated condition monitoring and control of fed-batch fermentation processes’, Journal of Process Control, 14 (1), 41-50

Zhang, H. and Lennox, B., (2003), ‘Multi-way optimal control of a benchmark fed-batch fermentation process’, Trans. InstMC, 25 (5), 403-417


Wu, L and Lennox, B, (2006), ‘Batch monitoring and control: a comparison of two approaches’, Control 2006, Glasgow


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