The conference brings together leading scientists in the field of hybrid quantum mechanics (QM)/molecular mechanics (MM) approaches, to discuss recent advances in QM/MM methodology and applications to systems of ever-increasing complexity and scale, ranging from exquisite enzyme catalysis to the chemistry and physics of smart materials. Organisers: Richard Bryce, Sam de Visser, Sam Hay The University of Manchester This meeting is organised on behalf of the MGMS and the University of Manchester The organisers would also like to thank the following sponsors for their support: