Tools for segmenting volumetric images

A set of programmes to enable annotation of regions of interest in volumetric images and to calculate volumes.
The tools are: Tools for Windows can be downloaded here.
A step-by-step description of how the tools to quantify white matter hyperintensity volumes from FLAIR MRIs can be used is in this PDF.
These tools were used in the paper:
Stefaniak JD, Parkes LM, Parry-Jones AR, Potter GM, Vail A, Jovanovic A, Smith CJ. "Enzyme replacement therapy and white matter hyperintensity progression in Fabry disease." Neurology 2018;91:1-10. doi:10.1212/WNL.0000000000006316 (here).