Manchester Applied Mathematics and Numerical Analysis Seminars Winter 1999/2000

January 12, 2000, 2.30 pm

Lecture Theatre OF/B9 Oddfellows Hall (Material Science)

Modelling the Onset of Atherosclerosis

Dr. N.A. Hill, Department of Applied Mathematics, University of Leeds

The thickening of the intimal layer of arteries which is a precursor to atherosclerosis is related (i) to transport of protein molecules across the endothelium which lines the artery and (ii) to the effects of low and oscillatory wall shear stress (WSS) on the permeability of the endothelium. In turn, the thickening changes the local geometry of the artery and affects the flow of blood and the WSS. Results from a mathematical model, which incorporates all of these effects, will presented. There is evidence that changes in the arterial wall with age lead to a greater likelihood of developing atherosclerotic palques.

For further info contact either Matthias Heil (mheil@ma.man.ac.uk), Mark Muldoon (M.Muldoon@umist.ac.uk)or the seminar secretary (Tel. 0161 275 5800).