Signalling

Inositol phospholipid signalling pathway

Protein kinase C (PKC)

  • DAG also activates PKC
  • PKC is calcium dependent
  • IP3 induced rise in Ca2+ alters PKC
  • Moves to cytosolic face of PM
  • Activated by Ca2+, DAG and phosphatidylserine
  • PKC then phosphorylates target proteins

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