Signalling

Cyclic AMP/cAMP

  • 1st id as a 2nd messenger in the 1950s
  • 10-7M intracellular concentration
  • An extracellular signal can ↑ x20 fold in seconds
  • cAMP is synthesised from ATP by pm bound adenylyl cyclase
  • cAMP is destroyed by cAMP phosphodiesterases to adenosine 5' monophosphate (5'AMP)

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