Signalling
Cyclic AMP/cAMP
- 1st id as a 2nd messenger in the 1950s
- 10-7M intracellular concentration
- An extracellular signal can ↑ x20 fold in seconds
- cAMP is synthesised from ATP by pm bound adenylyl cyclase
- cAMP is destroyed by cAMP phosphodiesterases to adenosine
5' monophosphate (5'AMP)