The plasma membrane

Phospholipase C

  • PM has phospholipases activated by extracellular signals to cleave specific phospholipids
  • Fragments are generated = short lived intracellular mediators
  • Phospholipase C cleaves an inositol phospholipid in cytosolic monolayer to form 2 fragments:
    1. 1 remains in PM where helps activate PKC
    2. 1 releasead into cytosol and stimulates release of Ca2+ from ER

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