Extracellular matrix

Non-collagen proteins

Fibronectin (Fn)

  • All forms of Fn are encoded by a single large gene
  • Alternative splicing of the RNA molecule to produce the various isoforms of Fn
  • Type III fibronectin repeat is the main type of module which binds to integrins
  • Contains specific tripeptide sequence Arg-Gly-Asp (RGD)
  • Major cell binding site

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