Extracellular matrix
Non-collagen proteins
Fibronectin (Fn)
- All forms of Fn are encoded by a single large gene
- Alternative splicing of the RNA molecule to produce the various
isoforms of Fn
- Type III fibronectin repeat is the main type of module
which binds to integrins
- Contains specific tripeptide sequence Arg-Gly-Asp (RGD)
- Major cell binding site