The cytoskeleton

Actin

Actin filament cross linking proteins:

  • Bundling proteins e.g fimbrin, α-actinin and villin
  • Gel-forming proteins e.g filamin found in lamellipodia

Severing proteins: Gelsolins

  • Activated by high levels of Ca2+
  • Accelerate assembly of new filament bundles
  • Speed up depolymerisation
  • Change mechanical properties: stiff large bundles and gels become more fluid

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