Cell Cycle Control

M-Cdks

  • Activation of M phase complexes trigger mitosis
  • G2 has 2 copies of entire genome - sister chromatids
  • Activation of mitosis occurs
  • M cyclin (cyclin B) accumulates
  • Subsequently M-Cdk accumulates
  • Activation requires dephosphorylation
  • Dephsophorylation requires activation of protein phosphatase Cdc25

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