Integrins
Integrins also activate intracellular signalling pathways
- Clustering of integrins at sites of contact intiate signalling
- Focal adhesion kinase (FAK), a protein tyrosine kinase is
involved in integrin signalling functions
- FAK is recruited to focal contacts by intracellular anchor
proteins
- Cross phosphorylation of FAK molecules causes production of
phosphotyrosine docking sites for the Src family of cytoplasmic
tyrosine kinases
- These phosphorylate FAK on additional tyrosines causing
production of docking sites for intracellular signalling proteins
- Signal is relayed into the cell