Bone Tissue Engineering

Natural materials: Hyaluronan

  • Natural proteoglycan of the ECM
  • Hyaluronan synthase enzymes synthesize large, linear polymers of the repeating disaccharide
  • Cells actively synthesize and catabolize hyaluronan throughout the lifetime of the tissue
  • The half life of a hyaluronan molecule in cartilage is normally 2-3 weeks
  • Resists compression and has role in mineralization

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