Bone 1

Mineralisation


Image obtained from Wheater's Functional Histology, Young and Heath Editors, Churchill Livingstone Publishers, 2002
  • Active osteoblasts secrete osteoid collagen (red) and matrix vesicles (yellow)
  • Matrix vesicles contain alkaline phosphatase and pyrophosphatase - produce phosphate ions
  • Mature compact bone contains 70% inorganic salts, 30% organic matrix
  • Collagen is 90% of the organic matrix the rest is proteoglycans and non-collagenous proteins
  • Bone collagen is 50% of the total body collagen - type 1 only
  • Less proteoglycans than in cartilage and are mainly chondroitin sulphate and hyaluronic acid
  • Non-collagenous proteins - osteocalcin, osteonectin and sialoproteins

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