Tissue Engineering

Introduction

Module Summary:

  • Introduction to tissue engineering
  • The need for tissue engineering and current surgical solutions:Disease states, ageing, trauma, transplants, autografts, xenografts
  • Cell sources: established cells, patient biopsies, stem cells, embryonic stem cells.
  • Biomaterials for tissue replacement: review current materials used in tissue replacement
  • Scaffolds for tissue engineering: development of appropriate scaffolds, scaffold properties, architecture, effects on cell responses, porosity
  • Mimicking the extracellular matrix: peptides, growth factors, proteases
  • Cell control via patterning and printing: controlling cell responses by patterned surfaces and printing specific molecules
  • Hydrogels: synthetic and natural materials as hydrogels
  • 3D generation of tissue: scaffold size limitations, regeneration of tissue, oxygen diffusion limitations, angiogenesis
  • Specific examples of tissue engineered tissues: bone, cartilage, tendon/ligament, skin, liver, intervertebral disc
  • Bioreactors: different methods for the culture of cells, rotary, flow perfusion
  • Gene therapy and tissue engineering
  • From concept to clinic: regulatory procedures, in vivo studies, patient trials, medical devices agency

Suggested reading:

  1. Principles of Tissue Engineering, Robert Lanza, Robert Langer, Joseph Vacanti. Academic Press, 2000.
  2. Biomaterials, medical devices, and tissue engineering : an integrated approach. Frederick H Silver. London : Chapman & Hall, 1994.
  3. Biomaterials Science, 1st Edition/2nd Edition, BD Ratner, AS Hoffman, FJ Schoen, Academic Press, 1996/2004.

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