Immune Responses
Soluble Mediators
Complement
Group of approx. 30 serum proteins, main function is control of inflammation but also mediate phagocytosis and interact with antibodies
- Complement activation is a cascade reaction
- 2 pathways: Classical and Alternative
Activation by either pathway generates protein molecules which cause:
- Opsonization of microorganisms for phagocytosis
- Chemotaxis
- Increased blood flow and capillary permeability
- Damage to plasma membranes of cells which have activated complement
- Release of other inflammatory mediators from mast cells
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