Toxicology 1

The Dose Response

What does the following data tell us?

Chloroform exposure: 6h/day for 7 days

EXPOSURE DOSE (ppm)SPECIESEFFECT
3MouseNo effect - Liver
10MouseMild liver damage
100MouseSevere liver damage
100MouseNo effect - Kidney
300MouseMild kidney injury
300MouseNo effect - Respiratory
3RatNo effect - Respiratory
10RatNasal injury
10RatNo effect - Kidney
30RatMild kidney injury
100RatNo effect - Liver
300RatMild liver damage

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