Toxicology 2
Biotransformation: Bioactivation vs Detoxification
Glutathione
- Conjugation with glutathione is an important reaction for sequestering reactive (toxic) metabolites
- These can be generated by cytochrome P450
- Glutathione S-transferases located in cytoplasm
- Glutathione conjugates undergo enzymatic cleavage and acetylation
forming mercapturic acid derivatives of the toxicants which are readily
excreted