Toxicology 2

Reactive Oxygen Intermediates

Pro-oxidants

• Free Radicals
• Species capable of independent existence that contains one or more unpaired electrons
• A molecule with an unpaired electron in an outer valance shell
• R₃C^., R₃O^., R₃N^., R₃S^.
• Non radicals
• Species that have strong oxidizing potential
• Species that favour the formation of strong oxidants (e.g. transition metals)
• Hydrogen peroxide H₂O₂, Hypochlorous acid HOCl^-, Ozone O₃, Singlet oxygen ¹O₂, Peroxynitrite ONOO^-, Transition metals Meⁿ⁺

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