Haemocompatibility and thrombogenicity
Heparin containing bioactive surfaces
- Repeating disaccharide unit of D-glucosamine and uronic acid
- Uronic acid = D-glucoronic acid or L-iduronic acid
- Some hydroxyl groups are sulphated
- Therefore highly negatively charged
- Central D-glucosamine residue contains a unique 3-O-sulfate moiety
- Elimination of sulphate groups decreases anticoagulant activity
- Removal of unique 3-O sulphate = complete loss of anticoagulant activity
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Lectures:
- Year 1:
- Cell Biology
- Year 2:
- Tissue Interactions and Biocompatibility
- Year 3/4:
- Tissue Engineering