PET data analysis - example of human studies with [11C]-(R)-PK11195
Presentation at the Biomedical Imaging Symposium Imaging neuroinflammation using PET
19 December 2007
Wolfson Molecular Imaging Centre
The University of Manchester
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Title
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Contents
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Part I: Introduction
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[11C]-(R)-PK11195 as an imaging marker
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Part II: PET scanning
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Sensitivity of PET
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What is specific activity?
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Analysis of radiolabelled metabolites
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Images
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Tissue time-activity curves
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Part III: Quantification of radioligand binding
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The standard model for receptor studies with PET 1
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The standard model for receptor studies with PET 2
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The simplified reference tissue model
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Parametric images
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Extraction of reference tissue kinetics
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[11C]-(R)-PK11195 studies at the WMIC
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Acknowledgements
Full presentation