Refereed
publications in primary journals:
1.
H.
Zhang, D. Nobel et al. (2003) “Dynamics of cardiac Ca2+ handling –
from experiments to virtual cells”. Int. J. Bifur & Chaos, in press.
2.
H.
Debronski, H. Zhang, AV Holden and MR Boyett (2003) “Molecular mapping and
electrophysilogical reconstruction of the pacemaker of the heart.” Int. J.
Bifur & Chaos, in press.
3.
Z.
Li, H. Zhang, AV Holden & C. Orchard (2003) “Modelling excitation and
propagation of action potentials across inhomogeneous ventricular tissue” Int.
J. Bifur & Chaos, in press.
4.
H.
Zhang et al. (2003) “Heterogeneous sinoatrial node of rabbit heart – molecular
and electric mapping and biophysical construction” LNCS 2674:
132-140.
5.
H.
Zhang, A.V.Holden, D. Noble and MR Boyett (2002) “Analysis pf the chronotropic
effect of acetylcholine on sinoatrial node” J. Cardiovas Electrophysiol,
Vol 13: 465-474.
6.
H.
Zhang, A.V.Holden and MR Boyett (2002) “Sustained inward current and pacemaker
activity of mammalian sinoatrial node.” J Cardiovasc Electrophysiol, Vol 13(8):809-12.
7.
M.R.Boyett,
H. Zhang, A.Garny, A.V.Holden (2001) "Control of the pacemaker of the
heart by intracellular Ca2+." Philosophical Transaction of Royal Society (London) A, 359 (1783): 1091-1110.
8.
M.R.Boyett,
A.V.Holden, H. Zhang (2001) “Engineering virtual cardiac tissue.” Briefings in Bioinformatics 2 (3): 233-244.
9.
H.
Zhang, A.V. Holden and M.R.Boyett (2001). "Gradient versus MOSAIC models
of rabbit sinoatrial node" Circulation,
103: 584-588.
10.
H.Zhang,
A.V.Holden and M.R.Boyett (2002). “Computational approaches to the ionic basis
of pacemaker activity-from channel kinetics to the regional differences in
rhythm”. Chaos, Soliton & Fractals,
13 (8): 1631-1642.
11. H Zhang, A.V.Holden,
I.Kodama, H.Honjo, M.Lei, T.Vagues & M.R.Boyett (2000)
"Mathematical models of action potentials in the periphery and centre of
the rabbit sinoatrial node", Journal
of American Physiology (Heart and Circulation), 279(1): H397-H421.
12. H. Zhang, A.V.Holden
and M.R.Boyett (2000). "Computer modelling the sinoatrial node". International Journal of
Bioelectromagnetism 2.
13. Z. Li, H. Zhang, A.V.Holden
and C.Orchard (2000). "Mathematical modelling of the electrical activity
of ventricular cardiac cells: regional differences and propagation". International Journal of Bioelectromagnesim
2.
14. M. deCastro,
M.Gomes-Gesteira, H. Zhang & V.Peres-Villar (2000) "Reentry
termination by infra and supra- threshold pulses" Chaos, Soliton and Fractals 11: 2031-2038.
15. H Zhang, R.L.Winslow,
A.V.Holden (1998) "Re-entrant excitation initiated in models of
inhomogeneous atrial tissue", Journal
of Theoretical Biology, 191 (3): 279-287.
16. Biktashev, V.N., Holden,
A.V., H Zhang (1997) "A model for the action of external current into
excitable tissue" International
Journal of Bifurcation and Chaos, Vol.7, No. 2: 477-485.
17. H Zhang, A.V.Holden,
M.R.Boyett (1997) "The pacemaking system of the heart: from coupled
oscillators to nonlinear waves", Nonlinear
Analysis-Theory Methods & Applications, Vol.30, No.2, pp.1019-1027
18. H Zhang, A.V.Holden (1997)
"One dimensional modelling the vulnerability to reentry of mammalian
atrial tissue", Journal of Theoretical
Biology, 184 (2) 119-124.
19. H Zhang (1996).
"Interactions between vortices and lesions and ectopic foci in a CML model
of cardiac tissue", International
Journal of Bifurcation and Chaos, Vol 6 no. 10.
20. X. Gong, F.Li, H Zhang
(1996). "On the control of chaotic neurons", Chaos, Soliton & Fractals, 7:
1397-1409.
21. M.Boyett, A.V.Holden,
I.Kodama, R.Suzuki, H. Zhang (1995). "Vagal control of sino-atrial node -
experiments and simulations". Chaos,
Soliton & Fractals 5: 425-438
22. H Zhang, A.V.Holden (1995).
"Spiral wave breakdown in an excitable medium model of cardiac
tissue". Chaos, Soliton &
Fractals 5: 661-672.
23. H Zhang, N.Patel.
"Chaotic meander spiral wave in FitzHugh-Nagumo systems". Chaos, Solitons & Fractals 5
(1995): 635-644.
24. A.V.Holden, H Zhang.
"Characteristics of atrial re-entry and meander computed from a model of a
rabbit single atrial cell". Journal
of Theoretical Biology 175 (1995): 545-551.
25. A.V.Holden, M.Poole,
J.V.Tucker and H Zhang. "Coupling CMLs and the synchronization of a
multiplayer neural computing system". Chaos,
Soliton and Fractals 4 (1994): 2249-2268.
26. V.N.Biktashev, A.V.Holden
and H Zhang. "Tension of the organising filament for scroll waves". Philosophical Transaction of Royal Society
347(1685) (1994) 611-630.
27. A.V.Holden, H Zhang.
"Modelling propagation and re-entry in anisotropic and smooth
heterogeneous cardiac tissue". Journal
of Chemic Society Faraday Transaction. 89(15) (1993):2833.
28. E.Labos, A.V.Holden and H
Zhang. "The behaviour of the Lyapunov exponent of a map simulating neural
activity". Physics Letter 173A
(1993) 399-406.
29. A.V.Holden, J.V.Tucker, H
Zhang, M.Poole. "Coupled map lattices as computational systems". Chaos 2 (1992) 367-376.
30. A.V.Holden and H Zhang.
"Lyapunov exponent spectrum for a generalised coupled map lattice". Chaos, Solitons & Fractals 2 (1992)
155-164.
31. H Zhang, A.V.Holden.
"Estimation of the persistence of strain from a time series as a measure
of the geometry of an attractor". Chaos,
Solitons & Fractals 2 (1992) 493.
32. H Zhang, A.V.Holden, M.Lab,
M.Moutoussis. "Estimation of the persistence of strain from experimental
recordings from cardiac tissue". Physica
58D (1992) 489-496.
Full
Papers submitted:
33.
H.
Zhang, A.V.Holden (2003) "Defibrillation threshold computed from normal
and supernormal excitable cardiac tissue”, submitted.
34.
C. Höper, G. Seemann, F.B. Sachse, H. Zhang, O.
Dössel (2003) “3D computer model of human atrial anatomy and
electrophysiology”, submitted.
35.
JJ
Borg, C Hancox, H Zhang, CI Spencer, RZ Kozlowski (2003) “Activators of the
cardiac anionic background current, IAB indicate its potential value
as a novel pharmacological target in the heart”, Circ Res, submitted.
36.
OV
Aslanidi, VN Biktashev, M Chen, RH Clayton, AV Holden, JV Tucker, H Zhang (2003)
“Computational biology of cardiac arrhythmias: from basic science to
application, submitted.
Abstracts:
37.
H.
Zhang, CJ Garratt, AV Holden (2003). “Competitive interaction between ectopic
foci and reentry in virtual human atrium” PACE 26, p985.
38.
H.
Zhang, CJ Garratt, AV Holden (2003). “Measured changes in sarcolemmal calcium
current cannot account for atrial action potential reduction in atrial
fibrillation” PACE 26, p977.
39.
I.V.
Biktasheva, A.V. Holden and H. Zhang, (2002). “Stability, period and meander of
spiral waves in two human virtual atrial tissues” J. Physiology (London),
544P.
40.
C.J.
Garratt, A.V. Holden and H. Zhang, (2002). “Cellular modelling of human atrial
tissue remodelling produced by atrial fibrillation”. J. Physiology (London),
544P.
41.
H.
Zhang, M. Lancaster, A.V. Holden & M.R. Boyett (2001) “Modelling of Ca2+
handling in the sinoatrial node – successes and failure”, Proceedings
of the Physiological Society of New Zealand vol 20 supplement 1.
42.
H.
Zhang, A.V. Holden & M.R. Boyett (2001) “ Mathematical modelling the
chronotropic effects of autonomous never system on the pacemaker activity of
rabbit sinoatrial node.” Proceedings of the Physiological Society of
New Zealand vol 20 supplement 1.
43.
H.
Zhang, H. Dobrzynski, I. Kodama, Takigishi, A.V. Holden & M.R. Boyett
(2001) “How does the sinoatrial node drive the atrium” J. Physiol, 536P.
44.
H.
Zhang, A.V.Holden, M.R.Boyett (2001) “Mathematical analysis of intracellular
Ca2+ regulation of the pacemaker activity of rabbit sinoatrial node. “ Journal of Physiology, 533: 30P-31P.
45.
H. Zhang, A.V.Holden, M.R.Boyett (2001)
“Modelling the effect of beta-adrenergic stimulation on rabbit sinoatrial node”
Journal of Physiology, 533: 38P-39P.
46.
A.
Garny, H. Zhang, M.R.Boyett, P. Khol, P. Noble & D. Noble (2000) "An
advanced computer models of rabbit sinoatruial node cells". Biophysical Journal, 78 No.1 Pt.2 p.P2674.
47. Z. Li, H.Zhang, A.V.Holden
& O. Clive (2000) "Regional differences in the ventricular wall of
guinea-pig heart: electrical activity and propagation" Journal of Physiology P. (London),
521P.
48. Garny, A., H. Zhang,
M.R.Boyett, P. Khol, P. Noble & D. Noble (2000) "Comparative studies
of models of rabbit sinoatrial node" Journal
of Physiology (London), 521P.
49. H Zhang, A.V.Holden, D.Noble
& M.R.Boyett (2000) "Modelling the chronotropic effects of
acetylchonine on the pacemaker activity of sinoatrial node" Journal of Physiology (London), 521P.
50. H Zhang, A.V.Holden,
I.Kodama, H. Honjo, M. Lei, Y. Takagishi, M.R.Boyett (1999) "Hypothesis to
explain the block zone protecting the sinoatrial node" Biophysics Journal Vol 76, No. 1 Pt2,
p.A368.
51. M.R.Boyett, I.Kodama,
M.R.Nikmaram, M.Yamamoto, H.Honjo, R.Niwa, H. Zhang, A.V.Holden (1998)
"Regional differences in the role of the rapid delayed rectifier K+
current, I(K,r), within the rabbit sinoatrial node", Journal of Physiology (LONDON), Vol. 511P, p.P7
52. H Zhang, Boyett, M.R.,
Holden, A.V., Honjo, H. and Kodama, I. (1998) "A hypothesis to explain the
decline of sinoatrial node function with age", Journal of Physiology, Vol.511P, pp.P76-P
53. H Zhang, Boyett, M.R.,
Holden, A.V., Honjo, H. and Kodama, I. (1998) "Evidence that the Na
current, INa, in the periphery of the sinoatrail node helps the node
to drive the surrounding atrial muscle" Journal of Physiology, Vol.506P, pp.P54-P55.
54. H Zhang, Boyett, M.R.,
Holden, A.V., Honjo, H. and Kodama, I. (1997) "A computer model of
pacemaker shift within the mammalian sinoatrial node" Journal of Physiology, vol.504P, p.P70.
55. Boyett, M.R., Holden, A.V.
& H Zhang. "Computational studies of electrotonic interactions between
sinoatrial node and atrium", European
Heart Journal 17, 293 1996.
56. H Zhang, M.R.Boyett,
A.V.Holden "Two dimensional studies of Electrotonic interactions between
sinoatrial node and atrium and effects of acetylcholine", Journal of Physiology, 497p pp.P 8-9 P,
1996.
57. H Zhang, R.L.Winslow.
"The role of the shift of the vulnerable window in initiation of reentrant
activity in models of mammanlian atrium". Journal of Physiology (London), vol.487P, pp.P 125-P 126, 1995
58. J. Blom, A.V.Holden,
M.Poole, J.V.Tucker and H Zhang. "Caress II: a general purpose tool for
parallel deterministic systems, with applications to simulating cellular
systems". Journal of Physiology
(London), 467, p145, 1993.
59. Clough, A., A.V.Holden and H
Zhang. "The effects of anisotropy on re-entrant wave in 3-dimensional,
coupled map lattice model of myocardial tissue". Journal of Physiol. (London), 467, p153, 1993
60. M.Boyett, A.V.Holden, H
Zhang. "Reconstruction of excitable tissue physiology and pathophysiology
from cellular models", In Computation in cellular and molecular biological
systems ed R Cutherbertson, M Holcombe, R Patton. pp 287-300 Singapore: World
Scientific 1996
61. K.Yip, H Zhang. Bifurcation
of kidney hemodynamics in hypertension. In: 1992 Lectures in Complex Systems.
Eds. L.Nadel, D.Stein, SFI Studies in Sciences of Complexity, Vol. V,
Addison-Wesley, 1993, p663-670.
62. H Zhang, A.V.Holden.
Measuring the complexity of attractors from single and multi-channel EEG
signals. In: 1992 Lectures in Complex Systems. Eds. L.Nadel, D.Stein, SFI
Studies in Sciences of Complexity, Vol. V, Addison-Wesley, 1993, p671-678.
63. A.V.Holden and H Zhang.
Nonlinear wave phenomena in cardiac tissue. In: Nonlinear dispersive wave. L.Debneath
(ed.), World Scientific Publisher, Singapore 1992.
64. A.V.Holden, J.Hyde and H
Zhang. Computing with unpredictable: Chaotic dynamics and Fractal structure of
the brain. In: Application of fractals and chaos. R.A.Earnshaw (ed.),
Springer-Verlag, Berlin 1993.
65.
A.V.Holden,
J.Hyde, M.Muhamad and H Zhang. Bifurcating neurones. In: Coupled oscillating
neurons. J.G.Taylor and G.L.T.Mannion (eds.), Springer-Verlag, Berlin.
66. A.V.Holden, J.V.Tucker,
B.C.Thompson, D.Withington and H Zhang. Theoretical framework for analyzing the
behaviour of real and simulated neural networks. In: Neural network dynamics.
J.G.Taylor, E.R.Caianiello, R.M.J.Cotterill and J.W.Clark (eds.),
Springer-Verlag, Berlin, 1992.
67.
A.V.Holden,
M.Muhamad and H Zhang. Spatio-temporal patterning and irregularity in neural
systems. In: Mathematical approaches to brain functioning diagnostics. I.
Dvorak and A.V.Holden (eds.), Manchester University Press, 1991.
International Conference Organizer/Session Chair:
Workshop on Cardiac
Calcium Handling – from Experiments to Virtual Cells, University of Leeds,
September 2002. Organizer & Session Chair.
Invited
Talks:
2001: UK
CytoCom Workshop “Modelling cell systems: the post genomic challenge” at UCL, March.
2001: Satellite
conference of 2001 World Congress of the International Union of Physiological
Sciences (IUPS) in Queen’s town, NewZeland, August (together with Prof. MR
Boyett).
2002: EPSRC
Network Workshop (International) on Engineering Virtual Tissue and Organs,
Leeds, June.
2002: Interface
between Physical Sciences and Biology, Manchester, May.
2003: Mathematical Biology, UCL, March.
Contribution
to conferences:
2003
(Talk): Functional imaging and modeling of the heart. Lyon, June.
2003
(2 Talks): 24th NASPE Annual Scientific meeting. Washington, May.
2002
(Talk & Demonstration): Meeting of Physiology Society, Leeds. September.
2002
(Invited talk): Interface between Physical Sciences and Biology, Manchester,
May.
2001
(Invited talk with Prof. Boyett): IUPS satellite meeting on Cardiac Modelling.
Queen’s town, NZ.
2001
(poster-1) IUPS satellite meeting on Cardiac modelling. Queen’s town, NZ.
2001
(poster-2) IUPS satellite meeting on Cardiac modelling. Queen’s town, NZ.
2001
(Talk) Meeting of
Physiological Society. Bristol, UK.
2001
(Invited Talk). Modelling Cell Systems: The Post Genome Challenge. UCL, UK.
2001
(talk)
Meeting of Physiological Society, Oxford, UK.
2001
(poster) Meeting of Physiological
Society, Oxford, UK.
2000
(talk)
CardioModel2000. Theory and application. Karlsruhe, Germany.
2000
(talk)
EPSRC virtual tissue engineering. Leeds.
1999 (talk) 23rd
meeting of the ESC working group on cardiac cellular electrophysiology, Oxford,
UK.
1999 (talk) Meeting of Physiological Society,
Glasgow, UK.
1999 (talk) 4th ESMTB meeting, SMB
annual meeting on Theory and Mathematics in Biology and Medicine, Amsterdam.
1998 (talk) Joint
meeting of Physiological Society, Prague, CZ.
1997 (talk) Meeting
of Physiological Society, Cambridge, UK.
1997 (talk) Meeting
of Physiological Society, Bristol, UK.
1996 (talk) Meeting
of Physiological Society, Leeds, UK.
1996 (talk) XVIII
th Congress of European Society of Cardiology, Birmingham, UK.
1996 (talk) 2nd
World Congress of Nonlinear Analysts, Athens, Greece.
1995 (talk) International
Workshop on Discretely-Coupled Dynamical Systems, Santiago de Compostela,
Spain.
1994 (poster) NATO
Workshop on Cardiac Excitable Medium, Leeds, UK.
1993 (talk) Meeting
of Physiological Society, Leeds, UK.
1992 (talk) CNLS
half day meeting on Nonlinear Dynamics, Leeds, UK.
1991 (poster) International
Congress of Nonlinear Dynamics, Warwick, UK.