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Warwicker Group
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Publications
Greaves RB, Warwicker J: Stability and solubility of proteins from extremophiles. Biochem Biophys Res Commun 2009 380:581-585. Bray T, Doig AJ, Warwicker J: Sequence and structural features of enzymes and their active sites by EC class. J Mol Biol 2009 386:1423-1436. Bougouffa S, Warwicker J: Volume-based solvation models out-perform area-based models in combined studies of wild-type and mutated protein-protein interfaces. BMC Bionformatics 2008 9:448. Kitchen J, Saunders RE, Warwicker J: Charge environments around phosphorylation sites in proteins. BMC Struct Biol 2008 8:19. Palmer B, Angus K, Taylor L, Warwicker J, Derrick JP: Design of stability at extreme alkaline pH in streptococcal protein G. J Biotechnol 2008 134:222-230. Liu B, Westhead DR, Boyett MR, Warwicker J: Modelling the pH-dependent Properties of Kv1 Potassium Channels. J Mol Biol 2007 368:328-335. Greaves RB, Warwicker J: Mechanisms for stabilisation and the maintenance of solubility in proteins from thermophiles. BMC Struct Biol 2007, 7(1):18. Iqbalsyah TM, Moutevelis E, Warwicker J, Errington N, Doig AJ: The CXXC motif at the N terminus of an alpha-helical peptide. Protein Sci 2006, 15(8):1945-1950. Chan P, Lovric J, Warwicker J: Subcellular pH and predicted pH-dependent features of proteins. Proteomics 2006, 6(12):3494-3501. Salaman MR, Warwicker J: Anomalies in the ionic properties of serum albumin. Proteins 2005, 61(3):468-472. Magee J, Warwicker J: Simulation of non-specific protein-mRNA interactions. Nucleic Acids Res 2005, 33(21):6694-6699. Lal K, Field MC, Carlton JM, Warwicker J, Hirt RP: Identification of a very large Rab GTPase family in the parasitic protozoan Trichomonas vaginalis. Mol Biochem Parasitol 2005, 143(2):226-235. Greaves R, Warwicker J: Active site identification through geometry-based and sequence profile-based calculations: burial of catalytic clefts. J Mol Biol 2005, 349(3):547-557. Warwicker J: Improved pKa calculations through flexibility based sampling of a water-dominated interaction scheme. Protein Sci 2004, 13(10):2793-2805. Moutevelis E, Warwicker J: Prediction of pKa and redox properties in the thioredoxin superfamily. Protein Sci 2004, 13(10):2744-2752. Magee JE, Warwicker J, Lue L: Freezing and folding behavior in simple off-lattice heteropolymers. J Chem Phys 2004, 120(23):11285-11291. Bate P, Warwicker J: Enzyme/non-enzyme discrimination and prediction of enzyme active site location using charge-based methods. J Mol Biol 2004, 340(2):263-276. Hirt RP, Lal K, Pinxteren J, Warwicker J, Healy B, Coombs GH, Field MC, Embley TM: Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis. Mol Biochem Parasitol 2003, 129(2):179-189. Phelan P, Gorfe AA, Jelesarov I, Marti DN, Warwicker J, Bosshard HR: Salt bridges destabilize a leucine zipper designed for maximized ion pairing between helices. Biochemistry 2002, 41(9):2998-3008. McCahill A, Warwicker J, Bolger GB, Houslay MD, Yarwood SJ: The RACK1 scaffold protein: a dynamic cog in cell response mechanisms. Mol Pharmacol 2002, 62(6):1261-1273. Cole C, Warwicker J: Side-chain conformational entropy at protein-protein interfaces. Protein Sci 2002, 11(12):2860-2870. Bolger GB, McCahill A, Yarwood SJ, Steele MR, Warwicker J, Houslay MD: Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5. BMC Biochem 2002, 3:24. Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR et al: TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid. J Biol Chem 2002, 277(31):28298-28309. Andrew CD, Warwicker J, Jones GR, Doig AJ: Effect of phosphorylation on alpha-helix stability as a function of position. Biochemistry 2002, 41(6):1897-1905. Doig AJ, Andrew CD, Cochran DAE, Hughes E, Kokkoni N, Penel S, Sun J-K, Stapley BJ, Warwicker J: Structure and stability of the alpha-helix. Research Developments in Protein Folding, Stability and Design 2002, 37:265-277. Warwicker J: Modelling of auxin-binding protein 1 suggests that its C-terminus and auxin could compete for a binding site that incorporates a metal ion and tryptophan residue 44. Planta 2001, 212(3):343-347. Ptushkina M, Berthelot K, von der Haar T, Geffers L, Warwicker J, McCarthy JE: A second eIF4E protein in Schizosaccharomyces pombe has distinct eIF4G-binding properties. Nucleic Acids Res 2001, 29(22):4561-4569. Karim MM, Hughes JM, Warwicker J, Scheper GC, Proud CG, McCarthy JE: A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1. J Biol Chem 2001, 276(23):20750-20757. Warwicker J, Cole C: The structural and spectroscopic basis for modelling prion protein interactions. Spectroscopy 2001, 15:151-159. Warwicker J: Modeling a prion protein dimer: predictions for fibril formation. Biochem Biophys Res Commun 2000, 278(3):646-652. Kajander T, Kahn PC, Passila SH, Cohen DC, Lehtio L, Adolfsen W, Warwicker J, Schell U, Goldman A: Buried charged surface in proteins. Structure 2000, 8(11):1203-1214. Warwicker J: Simplified methods for pKa and acid pH-dependent stability estimation in proteins: removing dielectric and counterion boundaries. Protein Sci 1999, 8(2):418-425. Warwicker J: Modelling charge interactions in the prion protein: predictions for pathogenesis. FEBS Lett 1999, 450(1-2):144-148. O'Connor J, Warwicker J: Prediction of peptides in the fermented cocoa storage protein, with reference to the modelled 3D structure. J Sci Food Agric 1998, 77:109-114. Warwicker J: Modeling charge interactions and redox properties in DsbA. J Biol Chem 1998, 273(5):2501-2504. Gane PJ, Dunwell JM, Warwicker J: Modeling based on the structure of vicilins predicts a histidine cluster in the active site of oxalate oxidase. J Mol Evol 1998, 46(4):488-493. Penfold R, Warwicker J, Jonsson B: Electrostatic models for calcium binding proteins. J Phys Chem B 1998, 102:8599-8610. Warwicker J: A molecular model for interfacial activation in phospholipase A2. FEBS Lett 1997, 404(2-3):159-163. Warwicker J: Species barriers in a model for specific prion protein dimerisation. Biochem Biophys Res Commun 1997, 232(2):508-512. Warwicker J: Improving pKa calculations with consideration of hydration entropy. Protein Eng 1997, 10(7):809-814. Warwicker J: A hypothesis describing a potential link between molecular structure and TSE strains. Biochem Biophys Res Commun 1997, 238(1):185-190. Warwicker J, Gane PJ: Calculation of Cys 30 delta pKa's and oxidising power for DsbA mutants. FEBS Lett 1996, 385(1-2):105-108. Warwicker J, Gane PJ: A model for prion protein dimerisation based on alpha-helical packing. Biochem Biophys Res Commun 1996, 226(3):777-782. Warwicker J, O'Connor J: A model for vicilin solubility at mild acidic pH, based on homology modelling and electrostatics calculations. Protein Eng 1995, 8(12):1243-1251. Sheffield PJ, Bhat KM, Owen AJ, Perry B, Sumner IG, Warwicker J: Increased activity of porcine pancreatic phospholipase A2 by designed long-range electrostatic stabilisation of the transition state. Biochem Biophys Res Commun 1995, 216(3):778-784. Gane PJ, Freedman RB, Warwicker J: A molecular model for the redox potential difference between thioredoxin and DsbA, based on electrostatics calculations. J Mol Biol 1995, 249(2):376-387. Warwicker J, Mueller-Harvey I, Sumner I, Bhat KM: The activity of porcine pancreatic phospholipase A2 in 20% alcohol/aqueous solvent, by experiment and electrostatics calculations. J Mol Biol 1994, 236(3):904-917. Warwicker J: Improved continuum electrostatic modelling in proteins, with comparison to experiment. J Mol Biol 1994, 236(3):887-903. Taylor MA, Baker KC, Connerton IF, Cummings NJ, Harris GW, Henderson IM, Jones ST, Pickersgill RW, Sumner IG, Warwicker J et al: An unequivocal example of cysteine proteinase activity affected by multiple electrostatic interactions. Protein Eng 1994, 7(10):1267-1276. Warwicker J: Model for the differential stabilities of rhinovirus and poliovirus to mild acidic pH, based on electrostatics calculations. J Mol Biol 1992, 223(1):247-257. Pickersgill RW, Sumner IG, Collins ME, Warwicker J, Perry B, Bhat KM, Goodenough PW: Modification of the stability of phospholipase A2 by charge engineering. FEBS Lett 1991, 281(1-2):219-222. Goodenough PW, Bhat KM, Collins ME, Perry BN, Pickersgill RW, Sumner IG, Warwicker J, de Haas GH, Verheij HM: Changes in activity of porcine phospholipase A2 brought about by charge engineering of a major structural element to alter stability. Protein Eng 1991, 4(8):929-934. Warwicker J: Investigating protein-protein interaction surfaces using a reduced stereochemical and electrostatic model. J Mol Biol 1989, 206(2):381-395. Warwicker J: A theoretical study of the acidification of the rhinovirus capsid. FEBS Lett 1989, 257(2):403-407. Warwicker J, Engelman BP, Steitz TA: Electrostatic calculations and model-building suggest that DNA bound to CAP is sharply bent. Proteins 1987, 2(4):283-289. Warwicker J: Continuum dielectric modelling of the protein-solvent system, and calculation of the long-range electrostatic field of the enzyme phosphoglycerate mutase. J Theor Biol 1986, 121(2):199-210. Warwicker J, Ollis D, Richards FM, Steitz TA: Electrostatic field of the large fragment of Escherichia coli DNA polymerase I. J Mol Biol 1985, 186(3):645-649. Warwicker J, Watson HC: Calculation of the electric potential in the active site cleft due to alpha-helix dipoles. J Mol Biol 1982, 157(4):671-679.
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