The plasma membrane
Phospholipase C
- PM has phospholipases activated by extracellular signals to
cleave specific phospholipids
- Fragments are generated = short lived intracellular mediators
- Phospholipase C cleaves an inositol phospholipid in
cytosolic monolayer to form 2 fragments:
- 1 remains in PM where helps activate PKC
- 1 releasead into cytosol and stimulates release of Ca2+
from ER