Baines Lab

Neural Development in Drosophila

 
   
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The development of a neural circuit requires precise synaptic interconnectivity and acquisition of appropriate electrical properties by constituent neurons. My research investigates the mechanisms that regulate the electrical development of neurons.
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This research uses the larvae of the fruitfly, Drosophila melanogaster, because this allows us to combine molecular genetics with electrophysiology.
Out & about
     
Once dissected, we use whole-cell patch recordings to both dye-label and record electrical properties of developing neurons.
       

move your mouse over the larvae to see inside

     
developmental timeline of the aCC motoneuron. Morphology upper panel and electrical properties lower panel (time axis = hours after egg laying)
                 
   

Research using flies at Manchester is facilitated by the

Manchester Fly Facility