Imaging neuroinflammation with PET - an overview of studies from Manchester
Presentation at the Friday Imaging Meeting
06 December 2019
Stopford G.706 and Wolfson Molecular Imaging Centre First Floor Meeting Room
The University of Manchester
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Title
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Introduction
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Methods
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Positron Emission Tomography (PET) of TSPO in the Brain
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Brain inflammation is induced by co-morbidities and risk factors for stroke
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[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
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[11C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches
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The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study
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Brain inflammation and psoriasis: a [11C]-(R)-PK11195 positron emission tomography study
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18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke.
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In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study
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Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats
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Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry
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Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe×PS1Δe9 transgenic mouse model of Alzheimer's disease.
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Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a PET study
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Assessing inflammation in acute intracerebral hemorrhage with PK11195 PET and dynamic contrast-enhanced MRI
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Microglial activation, white matter tract damage, and disability in MS
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Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma
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Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
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Microglial activation in patients with mild cognitive impairment: regional pattern and the correlation with apolipoprotein E gene status
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Neuroinflammation and changes in serotonin metabolism in presymptomatic HD gene carriers: a dual tracer positron emission tomography (PET) study - first results
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Summary and Outlook
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Acknowledgements
Full presentation