Imaging neuroinflammation with PET - an overview of studies from Manchester
Presentation at the Friday Imaging Meeting
06 December 2019
Stopford G.706 and Wolfson Molecular Imaging Centre First Floor Meeting Room
The University of Manchester
  1. Title
  2. Introduction
  3. Methods
  4. Positron Emission Tomography (PET) of TSPO in the Brain
  5. Brain inflammation is induced by co-morbidities and risk factors for stroke
  6. [18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
  7. [11C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches
  8. The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R)PK11195 PET imaging and neuropathology study
  9. Brain inflammation and psoriasis: a [11C]-(R)-PK11195 positron emission tomography study
  10. 18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke.
  11. In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study
  12. Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats
  13. Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry
  14. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe×PS1Δe9 transgenic mouse model of Alzheimer's disease.
  15. Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a PET study
  16. Assessing inflammation in acute intracerebral hemorrhage with PK11195 PET and dynamic contrast-enhanced MRI
  17. Microglial activation, white matter tract damage, and disability in MS
  18. Inflammation and vascular permeability correlate with growth in sporadic vestibular schwannoma
  19. Microglial activation in recent ischemic stroke: comparison of two TSPO tracers
  20. Microglial activation in patients with mild cognitive impairment: regional pattern and the correlation with apolipoprotein E gene status
  21. Neuroinflammation and changes in serotonin metabolism in presymptomatic HD gene carriers: a dual tracer positron emission tomography (PET) study - first results
  22. Summary and Outlook
  23. Acknowledgements

Full presentation