Our research concerns the development of novel techniques in high resolution NMR spectroscopy, and their application to problems in chemistry, biochemistry, and medicine. NMR is uniquely flexible, allowing great scope for ingenuity in modifying experiments to increase the amount of chemical information available from spectra. Multidimensional NMR methods can allow detailed structure determination for molecules as large as proteins, while recent advances in technique and instrumentation allow the non-invasive measurement of localised proton spectra of metabolites in human beings. Despite fifty years of development in both spectrometer hardware and experimental techniques, the pace of change shows no sign of slackening: NMR methods continue both to expand their range of application and to improve the ease with which they can be used to probe chemical, biochemical and biological structures.
Manchester is fortunate in being one of the best-equipped NMR research centres in the country, with eleven superconducting spectrometers in Chemistry alone. We have recently upgraded the NMR equipment, with the aid of a £1M grant from the EPSRC. In the Medical School there are first-class facilities for magnetic resonance imaging (MRI), with both whole-body and high-field small-bore systems. The School of Chemistry also hosts the national multi-frequency CW EPR service.
Among current and recent projects in NMR research are work on diffusion-ordered spectroscopy (DOSY), automated shimming methods, development of stabler NMR spectrometer hardware, and reference deconvolution methods for improved data processing, along with a variety of other applications of NMR spectroscopy and the analysis of magnetization transfer contrast phenomena in magnetic resonance imaging.
Old EPSRC final reports:
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Most recent revision 19th January 2010